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J Thorac Cardiovasc Surg 2002;124:798-805
© 2002 The American Association for Thoracic Surgery

Surgery for Congenital Heart Disease (CHD)

Valved jugular vein segments for right ventricular outflow tract reconstruction in young sheep

From the Department of Cardiac Surgery and Center for Experimental Surgery and Anesthesiology,^a the Department of Pathology,^b and the Department of Biostatistics,^c Katholieke Universiteit Leuven, Belgium.

Received for publication June 11, 2001. Revisions requested Aug 14, 2001; revisions received Oct 2, 2001. Accepted for publication Oct 8, 2001. Address for reprints: Willem Flameng, MD, CEHA, Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium (E-mail: willem.flameng{at}med.kuleuven.ac.be).

Objective: This study was undertaken to investigate the degeneration and calcification of valved bovine jugular vein segments for right ventricular outflow tract reconstruction in juvenile sheep.
Methods: Seven valved bovine jugular vein conduits (Contegra model 220; VenPro Corporation, Irvine, Calif) and 3 control conduits (MH100; Medtronic, Inc, Minneapolis, Minn) were implanted in the pulmonary artery in young sheep. After 20 weeks the conduits were explanted and qualitatively analyzed by epicardial echocardiography, gross examination, x-ray analysis, light microscopy, and transmission electron microscopy. Calcification was determined quantitatively by flame atomic absorption spectrometry.
Results: Two Contegra conduits could not be analyzed because of endocarditis. All other Contegra conduits functioned well, with preserved structure and minimal calcification. The control MH100 conduits exhibited extensive fibrous sheathing, with calcification of the aortic wall portion and the commissural part of the Hancock valve.
Conclusions: The Contegra conduit's performance was clearly superior to that of the control MH100 conduit when implanted in the pulmonary artery position in juvenile sheep for 5 months.

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