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J Thorac Cardiovasc Surg 2002;124:1007-1013
© 2002 The American Association for Thoracic Surgery
General Thoracic Surgery (GTS) |
From the Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Moriguchi,a the Division of Thoracic Surgery, Osaka Red Cross Hospital, Osaka,b the Division of Thoracic Surgery, Kurashiki Central Hospital, Kurashiki,c the Divisions of Thoracic Surgery of Hyogo Prefectural Amagasaki Hospitald and Hyogo Prefectural Tsukaguchi Hospital,e Hyogo, the Second Department of Surgery, Fukui Medical University, Fukui,f and the Division of Thoracic Surgery, Mie General Medical Center,g and the Department of Thoracic Surgery, Mie University of Medicine,h Mie, Japan.
Received for publication Dec 18, 2002. Revisions requested Feb 5, 2002; revisions received March 8, 2002. Accepted for publication March 24, 2002. Address for reprints: Yukihito Saito, MD, Associate Professor, Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, 10-15 Fumizonocho, Moriguchi, Osaka 570-8507, Japan (E-mail: saitoy{at}takii.kmu.ac.jp).
Objective: The purpose of this study was to analyze our entire experience with pulmonary resection for metastatic colorectal carcinoma to determine prognostic factors and critically evaluate the potential role of extended metastasectomy.
Methods: We analyzed the postoperative survival of 165 patients who underwent curative pulmonary surgery at eight institutions in the Kansai region of western Japan (Kansai Clinical Oncology Group) from 1990 to 2000.
Results: Overall survivals at 5 and 10 years were 39.6% and 37.2%, respectively. Cumulative survival of patients who underwent simultaneous bilateral metastasectomy was significantly lower than that of the patients who underwent unilateral metastasectomy or sequential bilateral metastasectomy (P = .048). Five-year survival was 53.6% for patients without hilar or mediastinal lymph node metastasis, versus 6.2% at 4 years for patients with metastases (P < .001). Five-year survival of patients with a prethoracotomy carcinoembryonic antigen level less than 10 ng/mL was 42.7%, versus 15.1% at 4 years for patients with a carcinoembryonic antigen level 10 ng/mL or greater (P < .0001). Twenty-one patients underwent a second or third thoracotomy for recurrent colorectal carcinoma. Overall 5-year survival from the date of the second thoracotomy was 52.1%. The 34.1% 10-year survival for the 26 patients with hepatic metastasis resected before thoracotomy did not differ significantly from that of patients without hepatic metastases (P = .38).
Conclusions: The status of the hilar or mediastinal lymph nodes and prethoracotomy carcinoembryonic antigen level were significant independent prognostic factors. Patients with pulmonary metastases potentially benefit from pulmonary metastasectomy even when there is a history of solitary liver metastasis. Careful follow-up is warranted, because patients with recurrent pulmonary metastases can undergo repeat thoracotomy with acceptable long-term survival. Simultaneous bilateral metastasectomy confers no survival benefit. Prospective studies may determine the significance of this type of pulmonary metastasectomy.
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