HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ashish Shah Donald D. Glower Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pasipoularides, A. D. Articles by Glower, D. D. Search for Related Content PubMed PubMed Citation Articles by Pasipoularides, A. D. Articles by Glower, D. D. Related Collections Cardiac - physiology

J Thorac Cardiovasc Surg 2002;124:964-972
© 2002 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology (CSP)

Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia

From the Department of Surgery, Division of Cardiothoracic Surgery, and the Duke Center for Emerging Cardiovascular Technologies, Duke University, Durham, NC.

This work was supported in part by National Heart, Lung, and Blood Institute grant R01 HL-50446 (Dr Pasipoularides) and the Duke/NSF ERC for Emerging Cardiovascular Technologies.

Received for publication Nov 6, 2001. Revisions requested Feb 5, 2002; revisions received April 4, 2002. Accepted for publication May 28, 2002. Address for reprints: Donald D. Glower, MD, Division of Cardiac and Thoracic Surgery, PO Box 3851, Medical Center, Duke University, Durham, NC 27710 (E-mail: glowe001{at}mc.duke.edu).

Objective: Limitations in clinical understanding of right ventricular relaxation can be attributed to the paucity of information from basic studies in animal models of right ventricular disease. This study examined, in the conscious state, right ventricular relaxation dynamics under normal conditions (n = 15) and in subacute (2-5 weeks) canine models of right ventricular pressure overload (n = 6), volume overload (n = 7), and free wall ischemia (n = 7).
Methods: Right-heart micromanometric measurements were obtained by using multisensor catheters. A new algorithm was developed to obtain representative ensemble averages of hemodynamic waveform data sets. Right ventricular relaxation was analyzed by using an exponential model with 3 parameters: P₀, , and P_b. Significant changes versus control values were determined by means of analysis of variance and the Student unpaired t test with Bonferroni's adjustment.
Results: In the state of pressure overload, right ventricular pressure decay exhibits an increased P₀ (56.2 ± 19.1 vs 13.1 ± 5.1 mm Hg [mean ± SD]) and prolonged (57.1 ± 2.8 vs 27.8 ± 3.9 ms); there is also a decreased P_b (-7.9 ± 1.5 vs 0.28 ± 1.8 mm Hg). The only significant change in volume overload is an increased asymptote, P_b (5.3 ± 2.9 mm Hg). In right ventricular ischemia, prolongation of (41.4 ± 13.0 ms) and decreased P_b (-1.95 ± 1.1 mm Hg) attain high significance.
Conclusions: Distinctive abnormalities in right ventricular relaxation dynamics accompany pressure overload, volume overload, and ischemia and may contribute to clinical right ventricular dysfunction.

This article has been cited by other articles:

				J. Mau, S. Menzie, M. Ward, H. Bundgaard, and S. Hunyor Time-dependent response of both ventricles after septal ablation: Implications for biventricular support after left ventricular assist device placement J. Thorac. Cardiovasc. Surg., September 1, 2007; 134(3): 579 - 586. [Abstract] [Full Text] [PDF]

				C. Cortina, J. Bermejo, R. Yotti, M. M. Desco, D. Rodriguez-Perez, J. C. Antoranz, J. L. Rojo-Alvarez, D. Garcia, M. A. Garcia-Fernandez, and F. Fernandez-Aviles Noninvasive Assessment of the Right Ventricular Filling Pressure Gradient Circulation, August 28, 2007; 116(9): 1015 - 1023. [Abstract] [Full Text] [PDF]

				J. van den Berg, P. A. Wielopolski, F. J. Meijboom, M. Witsenburg, A. J. J. C. Bogers, P. M. T. Pattynama, and W. A. Helbing Diastolic Function in Repaired Tetralogy of Fallot at Rest and during Stress: Assessment with MR Imaging Radiology, April 1, 2007; 243(1): 212 - 219. [Abstract] [Full Text] [PDF]

				Y. Sun, I. Belenkie, J.-J. Wang, and J. V. Tyberg Assessment of right ventricular diastolic suction in dogs with the use of wave intensity analysis Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3114 - H3121. [Abstract] [Full Text] [PDF]

				H. A. Leather, R. Ama', C. Missant, S. Rex, F. E. Rademakers, and P. F. Wouters Longitudinal but not circumferential deformation reflects global contractile function in the right ventricle with open pericardium Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2369 - H2375. [Abstract] [Full Text] [PDF]

				P. V. Kochupura, E. U. Azeloglu, D. J. Kelly, S. V. Doronin, S. F. Badylak, I. B. Krukenkamp, I. S. Cohen, and G. R. Gaudette Tissue-Engineered Myocardial Patch Derived From Extracellular Matrix Provides Regional Mechanical Function Circulation, August 30, 2005; 112(9_suppl): I-144 - I-149. [Abstract] [Full Text] [PDF]

				J.F. M. Bechtel, P. E. Lange, and H. H. Sievers Optimal Size of a Monocusp Patch for Reconstruction of a Hypoplastic Pulmonary Root: An Experimental Study in Pigs Ann. Thorac. Surg., June 1, 2005; 79(6): 2103 - 2108. [Abstract] [Full Text] [PDF]

				A. Pasipoularides, M. Shu, A. Shah, A. Tucconi, and D. D. Glower RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1956 - H1965. [Abstract] [Full Text] [PDF]

				A. Pasipoularides, M. Shu, A. Shah, M. S. Womack, and D. D. Glower Diastolic right ventricular filling vortex in normal and volume overload states Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1064 - H1072. [Abstract] [Full Text] [PDF]

				A. D. Pasipoularides, M. Shu, M. S. Womack, A. Shah, O. von Ramm, and D. D. Glower RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H56 - H65. [Abstract] [Full Text] [PDF]