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J Thorac Cardiovasc Surg 2003;125:1321-1327
© 2003 The American Association for Thoracic Surgery

General Thoracic Surgery

Pulmonary fibrosis and lung cancer: Risk and benefit analysis of pulmonary resection

From the Departments of Thoracic Surgery,^a Respiratory Medicine,^b Histopathology,^c and Radiology,^d Royal Brompton Hospital, London, United Kingdom.

Received for publication June 5, 2002. Revisions requested July 17, 2002; revisions received July 30, 2002. Accepted for publication Sept 17, 2002. Address for reprints: Mr. P. Goldstraw, FRCS, Department of Thoracic Surgery, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom (E-mail: p.goldstraw{at}rbh.nthames.nhs.uk).

Objective: Pulmonary fibrosis is associated with an increased risk of lung cancer and outcome of surgical resection in this setting is unknown.
Methods: We studied 22 patients (24 operations) with pulmonary fibrosis and non-small cell lung cancer treated between 1991 and 2000 (study group) and compared outcome with 951 other patients (964 operations) treatefor non-small cell lung cancer over the same period (control patients).
Results: The two groups did not differ significantly in age (68 vs 65 years), smoking history (86% vs 95% smokers), forced expiratory volume in 1 second (2.5 L/min vs 2.3 L/min) or forced vital capacity (3.2 L vs 3.7 L), but patients with pulmonary fibrosis were more likely to be male (72% vs 58%, P < .05). The operative mortality was higher in patients with pulmonary fibrosis than in control patients (17% vs 3.1%, P < .01) and there was a higher procedure-specific mortality in pulmonary fibrosis for pneumonectomy (33% vs 5.1%, P < .01) and lobectomy (12% vs 2.6%, P < .01). Patients with pulmonary fibrosis had a higher incidence of postoperative lung injury, (21% vs 3.7%, P < .01) and a longer mean hospital stay (17 vs 9 days, P < .05). In patients with pulmonary fibrosis, the actuarial 3-year survival was 54%. There were 11 deaths in the study group, 4 postoperatively (all acute respiratory distress syndrome) and 7 late deaths (metastatic disease, n = 2; progressive pulmonary fibrosis, n = 5). Median follow-up (to death or last review) was 13 months (range, 0-120 months). Five patients developed postoperative acute respiratory distress syndrome and in 4 of these patients this proved to be fatal. Postoperative acute respiratory distress syndrome was associated with lower preoperative total lung carbon monoxide diffusion capacity (median, 58% vs 70%, P = .03) and lower preoperative carbon monoxide diffusion capacity corrected for alveolar volume (median, 48% vs 58%, P = .05) and a higher preoperative composite physiological index (median, 44 vs 33, P = .008). None of the preoperative lung function parameters or operative finding were predictors of late death.
Conclusion: Patients with pulmonary fibrosis undergoing pulmonary resection for non-small cell lung cancer have increased postoperative morbidity and mortality, but an important subgroup has a good long-term outcome. Postoperative acute respiratory distress syndrome is associated with low preoperative gas transfer and a high composite physiological index. Resection of non-small cell lung cancer is appropriate in pulmonary fibrosis, provided that the level of functional impairment is carefully factored into patient selection.

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