JTCS Click here to go to SJM website.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Anil Apaydin
Hakan Posacioglu
Tanzer Calkavur
Suat Buket
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yagdi, T.
Right arrow Articles by Buket, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yagdi, T.
Right arrow Articles by Buket, S.
Related Collections
Right arrow Cardiac - pharmacology
Right arrow Coronary disease
Right arrow Electrophysiology - arrhythmias
Right arrowRelated Article

J Thorac Cardiovasc Surg 2003;125:1420-1425
© 2003 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology

Amiodarone reduces the incidence of atrial fibrillation after coronary artery bypass grafting

Tahir Yagdi, MD, Sanem Nalbantgil, MD, Fatih Ayik, MD, Anil Apaydin, MD, Fatih Islamoglu, MD, Hakan Posacioglu, MD, Tanzer Calkavur, MD, Yuksel Atay, MD, Suat Buket, MD

From the Ege University Medical Faculty, Department of Cardiovascular Surgery, zmir, Turkey.

Received for publication March 29, 2002. Revisions requested July 15, 2002; revisions received Aug 2, 2002. Accepted for publication Aug 15, 2002. Address for reprints: Tahir Yagdi, MD, Ege University Medical Faculty, Department of Cardiovascular Surgery, Bornova, Izmir 35100, Turkey (E-mail: tyagdi{at}med.ege.edu.tr).

Objective: The purpose of this study was to evaluate the safety and efficacy of postoperative administration of prophylactic amiodarone in the prevention of new-onset postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.
Methods: In this prospective study 157 patients were randomly divided into two groups: 77 patients (amiodarone group) received intravenous amiodarone in a dose of 10 mg/kg/d for postoperative 48 hours. On postoperative day 2 oral amiodarone was started with a dose of 600 mg/d for 5 days, 400 mg/d for the following 5 days, and 200 mg/d for 20 days, and 80 patients received placebo (control group).
Results: Preoperative patient characteristics and operative variables were similar in the two groups. Postoperative atrial fibrillation occurred in 8 patients (10.4%) receiving amiodarone and in 20 (25.0%) patients receiving placebo (P = .017). Duration of atrial fibrillation was 12.8 ± 4.8 hours for the amiodarone group compared with 34.7 ± 28.7 hours for the control group (P = .003). The maximum ventricular rate during atrial fibrillation was slower in the amiodarone group than in the control group (105.9 ± 19.1 beats per minute and 126.0 ± 18.5 beats per minute, respectively, P = .016). The two groups had a similar incidence of complication other than rhythm disturbances (20.8% vs 20.0%, P = .904). Amiodarone group patients had shorter hospital stays than that of control group patients (6.8 ± 1.7 days vs 7.8 ± 2.9 days, P = .014). The in-hospital mortality was not different between two groups (1.3% vs 3.8, P = .620).
Conclusions: Postoperative intravenous amiodarone, followed by oral amiodarone, appears to be effective in the prevention of new-onset postoperative atrial fibrillation. It also reduces ventricular rate and duration of atrial fibrillation after coronary artery bypass grafting. It is well tolerated and decreases the length of hospital stay.


Related Article

Is it time to choose amiodarone for postoperative atrial fibrillation?
Adam E. Saltman
J. Thorac. Cardiovasc. Surg. 2003 125: 1202-1203. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
J. E. Tisdale, H. A. Wroblewski, D. S. Wall, K. M. Rieger, Z. T. Hammoud, J. V. Young, and K. A. Kesler
A randomized trial evaluating amiodarone for prevention of atrial fibrillation after pulmonary resection.
Ann. Thorac. Surg., September 1, 2009; 88(3): 886 - 893.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
N. A. Haas and C. K. Camphausen
Impact of early and standardized treatment with amiodarone on therapeutic success and outcome in pediatric patients with postoperative tachyarrhythmia.
J. Thorac. Cardiovasc. Surg., November 1, 2008; 136(5): 1215 - 1222.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. R. Zebis, T. D. Christensen, I. S. Kristiansen, and V. E. Hjortdal
Amiodarone Cost Effectiveness in Preventing Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Ann. Thorac. Surg., January 1, 2008; 85(1): 28 - 32.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
F. Roshanali, M. H. Mandegar, M. A. Yousefnia, H. Rayatzadeh, F. Alaeddini, and F. Amouzadeh
Prediction of Atrial Fibrillation via Atrial Electromechanical Interval After Coronary Artery Bypass Grafting
Circulation, October 30, 2007; 116(18): 2012 - 2017.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. R. Zebis, T. D. Christensen, H. F. Thomsen, M. M. Mikkelsen, L. Folkersen, H. T. Sorensen, and V. E. Hjortdal
Practical Regimen for Amiodarone Use in Preventing Postoperative Atrial Fibrillation
Ann. Thorac. Surg., April 1, 2007; 83(4): 1326 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. C. Burgess, M. J. Kilborn, and A. C. Keech
Interventions for prevention of post-operative atrial fibrillation and its complications after cardiac surgery: a meta-analysis
Eur. Heart J., December 1, 2006; 27(23): 2846 - 2857.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. M. Bagshaw, P. D. Galbraith, L. B. Mitchell, R. Sauve, D. V. Exner, and W. A. Ghali
Prophylactic Amiodarone for Prevention of Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis
Ann. Thorac. Surg., November 1, 2006; 82(5): 1927 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. J. Barnes, E. A. Kirkland, P. A. Howard, D. W. Grauer, M. E. Gorton, J. B. Kramer, G. F. Muehlebach, and W. A. Reed
Risk-stratified evaluation of amiodarone to prevent atrial fibrillation after cardiac surgery.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1332 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
A. A. Patel, C. M. White, E. L. Gillespie, J. Kluger, and C. I. Coleman
Safety of amiodarone in the prevention of postoperative atrial fibrillation: A meta-analysis
Am. J. Health Syst. Pharm., May 1, 2006; 63(9): 829 - 837.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Dunning and P. McKeown
Are the american college of chest physicians guidelines for the prevention and management of atrial fibrillation after cardiac surgery already obsolete?
Chest, April 1, 2006; 129(4): 1112 - 1113.
[Full Text] [PDF]

Home page
 Crit Care NurseHome page
L. Brantman and J. Howie
Use of Amiodarone to Prevent Atrial Fibrillation After Cardiac Surgery
Crit. Care Nurse, February 1, 2006; 26(1): 48 - 58.
[Full Text] [PDF]

Home page
 JAMAHome page
L. B. Mitchell, D. V. Exner, D. G. Wyse, C. J. Connolly, G. D. Prystai, A. J. Bayes, W. T. Kidd, T. Kieser, J. J. Burgess, A. Ferland, et al.
Prophylactic Oral Amiodarone for the Prevention of Arrhythmias That Begin Early After Revascularization, Valve Replacement, or Repair: PAPABEAR: A Randomized Controlled Trial
JAMA, December 28, 2005; 294(24): 3093 - 3100.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. D. Aasbo, A. T. Lawrence, K. Krishnan, M. H. Kim, and R. G. Trohman
Amiodarone Prophylaxis Reduces Major Cardiovascular Morbidity and Length of Stay after Cardiac Surgery: A Meta-Analysis
Ann Intern Med, September 6, 2005; 143(5): 327 - 336.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
E. L Gillespie, C. I Coleman, S. Sander, J. Kluger, K. A Gryskiewicz, and C M. White
Effect of Prophylactic Amiodarone on Clinical and Economic Outcomes After Cardiothoracic Surgery: A Meta-Analysis
Ann. Pharmacother., September 1, 2005; 39(9): 1409 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
P. S. Myles and D. McIlroy
Fast-Track Cardiac Anesthesia: Choice of Anesthetic Agents and Techniques
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2005; 9(1): 5 - 16.
[Abstract] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
R. Kailasam, C. A. Palin, and C. W. Hogue Jr
Atrial Fibrillation After Cardiac Surgery: An Evidence-Based Approach to Prevention
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2005; 9(1): 77 - 85.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. DiDomenico and M. G. Massad
Pharmacologic Strategies for Prevention of Atrial Fibrillation After Open Heart Surgery
Ann. Thorac. Surg., February 1, 2005; 79(2): 728 - 740.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
U. Izhar, N. Ad, E. Rudis, E. Milgalter, A. Korach, N. Viola, E. Levi, G. Asraff, G. Merin, and A. Elami
When should we discontinue antiarrhythmic therapy for atrial fibrillation after coronary artery bypass grafting? A prospective randomized study
J. Thorac. Cardiovasc. Surg., February 1, 2005; 129(2): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
L. E. Samuels, E. C. Holmes, and F. L. Samuels
Selective Use of Amiodarone and Early Cardioversion for Postoperative Atrial Fibrillation
Ann. Thorac. Surg., January 1, 2005; 79(1): 113 - 116.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
J. Dunning, P. Botha, and M. Amanullah
Prophylactic Amiodarone effectively prevents post-operative atrial fibrillation
Interactive CardioVascular and Thoracic Surgery, September 1, 2004; 3(3): 510 - 515.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Yazigi, F. Haddad, S. Madi-Jebara, G. Sleilaty, and V. A. Jebara
Amiodarone for postoperative atrial fibrillation
J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 304 - 304.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The American Association for Thoracic Surgery.