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J Thorac Cardiovasc Surg 2003;125:1432-1437
© 2003 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology

No benefit of intraoperative whole blood sequestration and autotransfusion during coronary artery bypass grafting: Results of a randomized clinical trial

From the Department of Anesthesiology and Intensive Care,^a St Antonius Hospital, Nieuwegein, The Netherlands, and the Department of Pharmacotherapy and Pharmacoepidemiology,^b University of Utrecht, Utrecht, The Netherlands.

Received for publication July 30, 2001. Revisions requested Oct 24, 2001; revisions received June 12, 2002. Accepted for publication June 24, 2002. Address for reprints: J. A. Leusink, MD, PhD, Anesthesiologist, St Antonius Hospital, Department of Anesthesiology, Koekoekslaan 1, 3435 CM, Nieuwegein, Netherlands (E-mail: maatschap{at}anest-nieuwegein.net).

Objectives: In a randomized clinical trial of patients undergoing elective coronary artery bypass grafting, we evaluated the effect of intraoperative whole blood sequestration and autotransfusion on postoperative blood loss and the use of allogeneic blood products.
Methods: Male patients were included if it was possible to obtain at least 500 mL of autologous blood. For patients in group H (heparin autotransfusion, 50 patients; mean age 59 ± 8 years), an average of 670 ± 160 mL heparinized blood was drawn before bypass and reinfused after the period of the extracorporeal circulation. For patients in group C (citrate autotransfusion, 48 patients; mean age 60 ± 10 years), 450 ± 109 mL of citrate blood, drawn before administration of heparin, was used. Controls (N-group) consisted of 46 patients aged 62 ± 8 years. Strict transfusion criteria were used, and blood loss and use of allogeneic blood products during the hospital stays of all patients were recorded. Mean differences with their 95% confidence intervals adjusted for potential confounders were obtained by multiple linear regression.
Results: The mean difference (95% confidence interval) of blood loss of group H minus N was -93 mL (-307 to 139) and for C minus N was -66 mL (-186 to 179). The mean number of allogeneic blood transfusions for group H was 0.85 ± 1.74. Group C and group N used 0.94 ± 1.56 and 0.84 ± 1.24.
Conclusion: In coronary artery bypass grafting there is no effect of heparin or citrate intraoperative whole blood sequestration with regard to blood loss or use of allogeneic blood.

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