| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 2003;126:179-185
© 2003 The American Association for Thoracic Surgery
Cardiopulmonary support and physiology |
a Department of From the Departments of Anaesthesia, McMaster University, Hamilton, Ontario, Canada,
b Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Received for publication April 26, 2002 Received for publication July 8, 2002; revisions received September 12, 2002; accepted for publication October 17, 2002.
* Address for reprints: Robert M. K. W. Lee, PhD, Department of Anaesthesia (HSC-2U3), McMaster University, 1200 Main S West, Hamilton, Ontario, Canada, L8N 3Z5
rmkwlee{at}mcmaster.ca
OBJECTIVE: We sought to determine the effects of papaverine on human and canine internal thoracic artery function and structure.
METHODS: Vascular function was assessed with wire myography, and apoptosis was examined with confocal microscopy in arteries stained with ApopTag.
RESULTS: Acetylcholine-induced endothelium-dependent relaxation in phenylephrine-precontracted arteries was significantly impaired by papaverine treatment in both human and canine internal thoracic arteries (maximal relaxation: 68.35% ± 7.13% vs 47.5% ± 9.32% in human arteries and 74.8% ± 5.5% vs 34.3% ± 8.5% in canine arteries) but not by incubation with acidified saline solution (pH 3.9, which is equivalent to the pH of 10-2 mol/L papaverine solution) in canine internal thoracic arteries. Contraction of human internal thoracic arteries to phenylephrine or to U46619 was not significantly affected by papaverine treatment and neither was the contraction of canine internal thoracic arteries to phenylephrine. Total apoptotic endothelial and smooth muscle cells were significantly greater in papaverine-treated human and canine internal thoracic arteries.
CONCLUSIONS: Papaverine impairs endothelial function and triggers apoptosis of endothelial and smooth muscle cells of human and canine internal thoracic arteries. The long-term consequence of this impairment on vascular function is not known. Until this question is answered, it will be prudent to use other vasodilators that are less damaging to the internal thoracic artery for cardiac surgery.
This article has been cited by other articles:
|
|
 |
|
  S. Novella, A. C. Martinez, R. M. Pagan, M. Hernandez, A. Garcia-Sacristan, A. Gonzalez-Pinto, J. M. Gonzalez-Santos, and S. Benedito Plasma levels and vascular effects of vasopressin in patients undergoing coronary artery bypass grafting Eur. J. Cardiothorac. Surg., July 1, 2007; 32(1): 69 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bahcivan, F. Kolbakir, H. Karamustafa, and H T. Keceligil Endothoracic Papaverine Application for Internal Thoracic Artery Harvest Asian Cardiovasc Thorac Ann, June 1, 2007; 15(3): 234 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Gao, Z.-h. Zeng, K. Teoh, A. M. Sharma, L. Abouzahr, I. Cybulsky, A. Lamy, L. Semelhago, and R. M.K.W. Lee Perivascular adipose tissue modulates vascular function in the human internal thoracic artery J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1130 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kerendi, M. E. Halkos, J. S. Corvera, H. Kin, Z.-Q. Zhao, M. Mosunjac, R. A. Guyton, and J. Vinten-Johansen Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm Eur. J. Cardiothorac. Surg., December 1, 2004; 26(6): 1149 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hata, M. Shiono, T. Inoue, A. Sezai, N. Negishi, and Y. Sezai Midterm results of coronary artery bypass graft surgery with internal thoracic artery under low free-flow conditions Ann. Thorac. Surg., August 1, 2004; 78(2): 477 - 480. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
