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J Thorac Cardiovasc Surg 2003;126:80-89
© 2003 The American Association for Thoracic Surgery

Surgery for acquired cardiovascular disease

Long-term evaluation of Carpentier-Edwards porcine bioprosthesis for rheumatic heart disease

^a Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
^b Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
^c Far-East Memorial Hospital, Taipei, Taiwan

Received for publication May 21, 2002; accepted for publication September 9, 2002.

^* Address for reprints: Fang-Yue Lin, MD, Department of Surgery, National Taiwan University Hospital, No 7, Chung-Shan S. Rd, Taipei, Taiwan
fylin{at}ha.mc.ntu.edu.tw

OBJECTIVES: The clinical results of Carpentier-Edwards standard bioprosthesis have been extensively studied for valvular heart surgery in America and Europe. However, the data of long-term performance of Carpentier-Edwards standard porcine valve in areas with a high prevalence of rheumatic heart disease are still lacking. In this study, we assessed the clinical performance of Carpentier-Edwards standard porcine bioprostheses in a patient group with high prevalence of rheumatic heart disease.

METHODS: A total of 872 patients underwent valvular heart surgery with Carpentier-Edwards standard porcine bioprostheses replacement between 1975 and 1999 and the results were analyzed. Rheumatic etiology counts for 95% of the patients. Mean age of operation was 40 ± 14 years (mitral valve), 43 ± 19 years (aortic valve), and 45 ± 13 years (double valve). Follow-up was 95.6% complete and continued up to 24 years (total 7017 patient-years) with mean of 8.9 ± 5.1 years.

RESULTS: The operative mortality rate was 5.85%. Actuarial patient survival rates after discharge at 5, 10, 15, and 20 years were 92.5%, 83.8%, 72.3%, and 35.8%, respectively. A total of 442 cases received reoperation due to failure of bioprostheses. The mean duration to valve failure is 12.2 ± 0.4 years. Actuarial estimate of freedom from structural valvular failure at 5, 10, 15, and 20 years were 96.3%, 63.7%, 24.4%, and 7.7%, respectively.

CONCLUSION: The long-term result of Carpentier-Edwards standard bioprostheses in the present patient group is satisfactory. However, freedom from valve failure is lower than that of Western series. Younger age at operation and higher prevalence of rheumatic etiology in this area are possible causes.

Key Words: 35

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