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J Thorac Cardiovasc Surg 2003;126:783-793
© 2003 The American Association for Thoracic Surgery
Surgery for acquired cardiovascular disease |
a Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA,
b Department of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, OhioUSA
c The University of British Columbia, Vancouver, British Columbia, Canada
d Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NHUSA
e Northwest Surgical Associates, Portland, OreUSA
f Stanford University, Stanford, CalifUSA
g University Hospital, Cardiff, United Kingdom
h Instituto Chirurgia Cardiovascolare, University of Padova, Padova, Italy
i Harefield Hospital, London, United Kingdom
j Edwards Lifesciences Corporation, Irvine, CalifUSA
Read at the Eightieth Annual Meeting of The American Association for Thoracic Surgery, Toronto, Ontario, Canada, April 30–May 3, 2000.
Received for publication April 28, 2000; revisions received November 27, 2002; accepted for publication February 26, 2003.
* Address for reprints: Eugene H. Blackstone, MD, The Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F25, Cleveland, OH 44195, USA
blackse{at}ccf.org
OBJECTIVE: This study was undertaken to quantify the relationship between prosthesis size adjusted for patient size (prosthesis-patient size) and long-term survival after aortic valve replacement.
METHODS: Data from nine representative sources on 13,258 aortic valve replacements provided 69,780 patient-years of follow-up (mean 5.3 ± 4.7 years), with reliable survival estimates to 15 years. Prostheses included 5757 stented porcine xenografts, 3198 stented bovine pericardial xenografts, 3583 mechanical valves, and 720 allografts. Manufacturers’ labeled prosthesis size was 19 mm or smaller in 1109 patients. Expressions of prosthesis-patient size assessed were indexed internal prosthesis orifice area (in centimeters squared per square meter of body surface area) and standardized internal prosthesis orifice size (Z, the number of SDs from mean normal native aortic valve size). Multivariable hazard domain analysis with balancing score and risk factor adjustment quantified the association of prosthesis-patient size with survival.
RESULTS: Prosthesis-patient size down to at least 1.1 cm2/m2 or -3 Z did not adversely affect intermediate- or long-term survival (P > .2). However, 30-day mortality increased 1% to 2% when indexed orifice area fell below 1.2 cm2/m2 (P = .002) or standardized orifice size fell below -2.5 Z (P = .0003). The increased early risk affected fewer than 1% of patients receiving bioprostheses but about 25% of those receiving mechanical devices.
CONCLUSIONS: Aortic prosthesis-patient size down to 1.1 cm2/m2 or -3 Z did not reduce intermediate- or long-term survival after aortic valve replacement. However, patient-prosthesis size under 1.2 cm2/m2 or -2.5 Z was associated with a 1% to 2% increase in 30-day mortality. Prosthesis-patient sizes this small or smaller were rarely implanted in patients receiving bioprostheses.
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P. Pibarot, J. G. Dumesnil, G. Tasca, C. G. Koch, F. Khandwala, F. G. Estafanous, F. D. Loop, and E. H. Blackstone Letter Regarding Article by Koch et al, "Impact of Prothesis-Patient Size on Functional Recovery After Aortic Valve Replacement" * Response Circulation, November 22, 2005; 112(21): e333 - e333. [Full Text] [PDF]
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C. G. Koch, F. Khandwala, F. G. Estafanous, F. D. Loop, and E. H. Blackstone Impact of Prosthesis-Patient Size on Functional Recovery After Aortic Valve Replacement Circulation, June 21, 2005; 111(24): 3221 - 3229. [Abstract] [Full Text] [PDF]
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H.-H. Sievers Prosthetic aortic valve replacement J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 961 - 965. [Full Text] [PDF]
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R. G. Fuster, J. A. M. Argudo, O. G. Albarova, F. H. Sos, S. C. Lopez, M. B. Codoner, J. A. B. Minano, and I. R. Albarran Patient-prosthesis mismatch in aortic valve replacement: really tolerable? Eur. J. Cardiothorac. Surg., March 1, 2005; 27(3): 441 - 449. [Abstract] [Full Text] [PDF]
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C. Amarelli, A. Della Corte, G. Romano, G. Iasevoli, G. Dialetto, L. S. De Santo, M. De Feo, M. Torella, M. Scardone, and M. Cotrufo Left ventricular mass regression after aortic valve replacement with 17-mm St Jude Medical mechanical prostheses in isolated aortic stenosis J. Thorac. Cardiovasc. Surg., March 1, 2005; 129(3): 512 - 517. [Abstract] [Full Text] [PDF]
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M. Gaudino, F. Alessandrini, F. Glieca, N. Luciani, C. Cellini, C. Pragliola, M. Morelli, C. Canosa, G. Nasso, and G. Possati Survival after aortic valve replacement for aortic stenosis: does left ventricular mass regression have a clinical correlate? Eur. Heart J., January 1, 2005; 26(1): 51 - 57. [Abstract] [Full Text] [PDF]
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J. G. Dumesnil and P. Pibarot Prosthesis size and prosthesis-patient size are unrelated to prosthesis-patient mismatch J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1852 - 1852. [Full Text] [PDF]
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E. H. Blackstone, A. M. Gillinov, and D. M. Cosgrove Reply to the Editor J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1852 - 1854. [Full Text] [PDF]
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