HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chiyo, M. Articles by Fujisawa, T. Search for Related Content PubMed PubMed Citation Articles by Chiyo, M. Articles by Fujisawa, T. Related Collections Lung - cancer

J Thorac Cardiovasc Surg 2003;126:1141-1146
© 2003 The American Association for Thoracic Surgery

General thoracic surgery

Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes

^a Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
^b Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan

Received for publication July 22, 2002; revisions received October 11, 2002; revisions received February 17, 2003; accepted for publication March 24, 2003.

^* Address for reprints: Yasuo Sekine, MD, Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
yasuo-sekine{at}umin.ac.jp

BACKGROUND: This study investigated postoperative morbidity, mortality, and the long-term survival for patients with lung cancer who have interstitial lung diseases.

METHODS: A retrospective chart review of 931 patients with lung cancer who underwent pulmonary resection at Chiba University Hospital between 1990 and 2000 was undertaken. Interstitial lung disease was defined by medical history, physical examination, and abnormalities compatible with bilateral lung fibrosis on chest computed tomography or high-resolution computed tomography (36 patients: 3.9%, interstitial lung diseases group). The remaining 895 patients (96.1%) were categorized as non–interstitial lung disease group.

RESULTS: The incidence of postoperative pneumonia and acute or exacerbation of interstitial pneumonia was higher in the interstitial lung disease group (all P < .05). Thirty-day mortality was statistically equivalent between the interstitial lung disease and the non–interstitial lung disease groups (P = .30). The 5-year overall survivals were 62.5% (non–interstitial lung disease) and 35.6% (interstitial lung disease). Respiratory failure was the second main cause of death after the recurrence of primary cancer in the interstitial lung disease group. The risk factors for long-term mortality were interstitial lung diseases, advanced pathologic stage, male sex, high age, and positive smoking history (all P < .05).

CONCLUSIONS: Interstitial lung disease was a risk factor for developing postoperative morbidity and mortality and poor long-term survival due to the occurrence of respiratory failure.

This article has been cited by other articles:

				E. R. Fernandez-Perez, M. Yilmaz, H. Jenad, C. E. Daniels, J. H. Ryu, R. D. Hubmayr, and O. Gajic Ventilator Settings and Outcome of Respiratory Failure in Chronic Interstitial Lung Disease Chest, May 1, 2008; 133(5): 1113 - 1119. [Abstract] [Full Text] [PDF]

				P. Tonnesen, L. Carrozzi, K. O. Fagerstrom, C. Gratziou, C. Jimenez-Ruiz, S. Nardini, G. Viegi, C. Lazzaro, I. A. Campell, E. Dagli, et al. Smoking cessation in patients with respiratory diseases: a high priority, integral component of therapy Eur. Respir. J., February 1, 2007; 29(2): 390 - 417. [Abstract] [Full Text] [PDF]