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Sunil M. Prasad
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J Thorac Cardiovasc Surg 2003;126:1822-1827
© 2003 The American Association for Thoracic Surgery


Cardiopulmonary support and physiology

The Cox maze III procedure for atrial fibrillation: long-term efficacy in patients undergoing lone versus concomitant procedures

Sunil M. Prasad, MDa, Hersh S. Maniar, MDa, Cindy J. Camillo, RNa, Richard B. Schuessler, PhDa, John P. Boineau, MDa, Thoralf M. Sundt, III, MDa, James L. Cox, MDa, Ralph J. Damiano, Jr, MD*,a

a Division of Cardiothoracic Surgery, Barnes-Jewish Hospital, Washington University School of Medicine, St Louis, Mo, USA

Read at the Eighty-second Annual Meeting of The American Association for Thoracic Surgery, Washington, DC, May 5-8, 2002.

Received for publication October 11, 2002; revisions received January 17, 2003; accepted for publication April 14, 2003.

* Address for reprints: Ralph J. Damiano, Jr, MD, Chief of Cardiac Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, One Barnes-Jewish Plaza, Queeny Tower Suite 3108, St Louis, MO 63110, USA
damiano{at}msnotes.wustl.edu

BACKGROUND: For the last decade, the Cox maze III procedure has been available for the treatment of atrial fibrillation. It is unknown whether the operation has similar efficacy in patients with lone atrial fibrillation compared with that in patients with atrial fibrillation associated with coronary, valve, or congenital heart disease. This study examined the long-term outcome of patients who underwent this procedure either as a lone operation or as a concomitant procedure.

METHODS: From 1988 to 2001, 198 patients underwent a Cox maze III procedure; 112 were lone operations, and 86 were concomitant procedures. Major complications included renal failure, reoperation for bleeding, mediastinitis, stroke, and balloon pump insertion. Follow-up was performed by means of mail and telephone questionnaires with both the patients and their cardiologists. All patients who had any history of arrhythmia or who were taking medication had their rhythm documented by means of electrocardiography.

RESULTS: The lone operation group was significantly younger (51.3 ± 10.5 vs 58.8 ± 9.9 years) and had a higher male/female ratio (4:1 vs 2:1). There was no difference in operative mortality between groups (1.8% vs 1.2%). At a follow-up of 5.4 ± 2.9 years, 96.6% (172/178) of all patients were free of atrial fibrillation. There was no difference between the lone operation and concomitant procedure groups (95.9% vs 97.5%).

CONCLUSION: The Cox maze III procedure has equivalent operative risk and long-term efficacy in patients undergoing both lone operations and concomitant procedures. The Cox maze III procedure remains the standard against which alternative procedures for atrial fibrillation must be judged.





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Ann. Thorac. Surg.Home page
S. L. Gaynor, G. D. Byrd, M. D. Diodato, Y. Ishii, A. M. Lee, S. M. Prasad, J. Gopal, R. B. Schuessler, and R. J. Damiano Jr
Microwave Ablation for Atrial Fibrillation: Dose-Response Curves in the Cardioplegia-Arrested and Beating Heart
Ann. Thorac. Surg., January 1, 2006; 81(1): 72 - 76.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
A. M. Gillinov, J. Sirak, E. H. Blackstone, P. M. McCarthy, J. Rajeswaran, G. Pettersson, F. J. Sabik III, L. G. Svensson, J. L. Navia, D. M. Cosgrove, et al.
The Cox maze procedure in mitral valve disease: Predictors of recurrent atrial fibrillation
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1653 - 1660.
[Abstract] [Full Text] [PDF]


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MMCTSHome page
S. Benussi and O. Alfieri
Concomitant ablation of atrial fibrillation during mitral surgery
MMCTS, November 29, 2005; 2005(1129): 1081.
[Abstract] [Full Text] [PDF]


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JAMAHome page
T. M. Sundt and B. J. Gersh
Making Sense of the Maze: Which Patients With Atrial Fibrillation Will Benefit?
JAMA, November 9, 2005; 294(18): 2357 - 2359.
[Full Text] [PDF]


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Ann. Thorac. Surg.Home page
G. M. Guiraudon, D. L. Jones, A. C. Skanes, D. Bainbridge, C. M. Guiraudon, S. M. Jensen, X. Yuan, M. Drangova, and T. M. Peters
En Bloc Exclusion of the Pulmonary Vein Region in the Pig Using Off Pump, Beating, Intra-Cardiac Surgery: A Pilot Study of Minimally Invasive Surgery for Atrial Fibrillation
Ann. Thorac. Surg., October 1, 2005; 80(4): 1417 - 1423.
[Abstract] [Full Text] [PDF]


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ChestHome page
M.-C. Chen, J.-P. Chang, C.-J. Chen, C.-H. Yang, W. C. Hung, M. Fu, and K.-H. Yeh
Atrial Pacemaker Complex Preserved Radiofrequency Maze Procedure Reducing the Incidence of Sick Sinus Syndrome in Patients With Atrial Fibrillation
Chest, October 1, 2005; 128(4): 2571 - 2575.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
J. S. Gammie, J. C. Laschinger, J. M. Brown, R. S. Poston, R. N. Pierson III, L. G. Romar, K. L. Schwartz, M. J. Santos, and B. P. Griffith
A Multi-Institutional Experience With the CryoMaze Procedure
Ann. Thorac. Surg., September 1, 2005; 80(3): 876 - 880.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
J. Ninet, X. Roques, R. Seitelberger, C. Deville, J. L. Pomar, J. Robin, O. Jegaden, F. Wellens, E. Wolner, C. Vedrinne, et al.
Surgical ablation of atrial fibrillation with off-pump, epicardial, high-intensity focused ultrasound: Results of a multicenter trial
J. Thorac. Cardiovasc. Surg., September 1, 2005; 130(3): 803 - 803.
[Abstract] [Full Text] [PDF]


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CirculationHome page
C. A. Mack, F. Milla, W. Ko, L. N. Girardi, L. Y. Lee, A. J. Tortolani, J. Mascitelli, K. H. Krieger, and O. W. Isom
Surgical Treatment of Atrial Fibrillation Using Argon-Based Cryoablation During Concomitant Cardiac Procedures
Circulation, August 30, 2005; 112(9_suppl): I-1 - I-6.
[Abstract] [Full Text] [PDF]


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CirculationHome page
G. D. Byrd, S. M. Prasad, C. M. Ripplinger, T. R. Cassilly, R. B. Schuessler, J. P. Boineau, and R. J. Damiano Jr
Importance of Geometry and Refractory Period in Sustaining Atrial Fibrillation: Testing the Critical Mass Hypothesis
Circulation, August 30, 2005; 112(9_suppl): I-7 - I-13.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
S. Benussi, S. Nascimbene, G. Calori, P. Denti, Z. Ziskind, S. Kassem, G. La Canna, C. Pappone, and O. Alfieri
Surgical ablation of atrial fibrillation with a novel bipolar radiofrequency device
J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 491 - 497.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
M. E. Halkos, J. M. Craver, V. H. Thourani, F. Kerendi, J. D. Puskas, W. A. Cooper, and R. A. Guyton
Intraoperative Radiofrequency Ablation for the Treatment of Atrial Fibrillation During Concomitant Cardiac Surgery
Ann. Thorac. Surg., July 1, 2005; 80(1): 210 - 216.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
M. E. Goldman and L. B. Croft
Atrial Fibrillation: The Ancient Conundrum Defies Simple Solution
J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1813 - 1814.
[Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
K. Bando, H. Kasegawa, Y. Okada, J. Kobayashi, A. Kada, T. Shimokawa, M. Nasu, S. Nakatani, K. Niwaya, O. Tagusari, et al.
Impact of preoperative and postoperative atrial fibrillation on outcome after mitral valvuloplasty for nonischemic mitral regurgitation
J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1032 - 1040.
[Abstract] [Full Text] [PDF]


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ICVTSHome page
M.-J. Baek, S.-S. Oh, C.-H. Lee, and C.-Y. Na
Outcome of the modified maze procedure for atrial fibrillation combined with rheumatic mitral valve disease using cryoablation
Interactive CardioVascular and Thoracic Surgery, April 1, 2005; 4(2): 130 - 134.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
C. C. Lang, V. Santinelli, G. Augello, A. Ferro, F. Gugliotta, S. Gulletta, G. Vicedomini, C. Mesas, G. Paglino, S. Sala, et al.
Transcatheter radiofrequency ablation of atrial fibrillation in patients with mitral valve prostheses and enlarged atria: Safety, feasibility, and efficacy
J. Am. Coll. Cardiol., March 15, 2005; 45(6): 868 - 872.
[Abstract] [Full Text] [PDF]


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CirculationHome page
S. J. Hazel, H. S. Paterson, J. R.M. Edwards, and G. J. Maddern
Surgical Treatment of Atrial Fibrillation via Energy Ablation
Circulation, March 1, 2005; 111(8): e103 - e106.
[Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
T. Nitta, H. Ohmori, S.-i. Sakamoto, Y. Miyagi, S. Kanno, and K. Shimizu
Map-guided surgery for atrial fibrillation
J. Thorac. Cardiovasc. Surg., February 1, 2005; 129(2): 291 - 299.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
S. L. Gaynor, R. B. Schuessler, M. S. Bailey, Y. Ishii, J. P. Boineau, M. J. Gleva, J. L. Cox, and R. J. Damiano Jr
Surgical treatment of atrial fibrillation: Predictors of late recurrence
J. Thorac. Cardiovasc. Surg., January 1, 2005; 129(1): 104 - 111.
[Abstract] [Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
J. L. Monro
The next challenge--adapting to change
Eur. J. Cardiothorac. Surg., December 1, 2004; 26(6): 1063 - 1072.
[Full Text] [PDF]


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Eur. J. Cardiothorac. Surg.Home page
S. Benussi
Treatment of atrial fibrillation
Eur. J. Cardiothorac. Surg., December 1, 2004; 26(Suppl_1): S39 - S41.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
N. A. Mokadam, P. M. McCarthy, A. M. Gillinov, W. H. Ryan, M. R. Moon, M. J. Mack, S. L. Gaynor, S. M. Prasad, S. A. Wickline, M. S. Bailey, et al.
A Prospective Multicenter Trial of Bipolar Radiofrequency Ablation for Atrial Fibrillation: Early Results
Ann. Thorac. Surg., November 1, 2004; 78(5): 1665 - 1670.
[Abstract] [Full Text] [PDF]


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Ann. Thorac. Surg.Home page
S. L. Gaynor, Y. Ishii, M. D. Diodato, S. M. Prasad, K. M. Barnett, N. R. Damiano, G. D. Byrd, S. A. Wickline, R. B. Schuessler, and R. J. Damiano Jr
Successful Performance of Cox-Maze Procedure on Beating Heart Using Bipolar Radiofrequency Ablation: A Feasibility Study in Animals
Ann. Thorac. Surg., November 1, 2004; 78(5): 1671 - 1677.
[Abstract] [Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
S. L. Gaynor, M. D. Diodato, S. M. Prasad, Y. Ishii, R. B. Schuessler, M. S. Bailey, N. R. Damiano, J. B. Bloch, M. R. Moon, and R. J. Damiano Jr
A prospective, single-center clinical trial of a modified Cox maze procedure with bipolar radiofrequency ablation
J. Thorac. Cardiovasc. Surg., October 1, 2004; 128(4): 535 - 542.
[Abstract] [Full Text] [PDF]


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CirculationHome page
Y. Ishii, M. J. Gleva, M. C. Gamache, R. B. Schuessler, J. P. Boineau, M. S. Bailey, and R. J. Damiano Jr
Atrial Tachyarrhythmias After the Maze Procedure: Incidence and Prognosis
Circulation, September 14, 2004; 110(11_suppl_1): II-164 - II-168.
[Abstract] [Full Text] [PDF]


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ChestHome page
R. M. John and G. Michaud
Atrial Fibrillation: Nonpharmacologic Therapies Coming of Age
Chest, June 1, 2004; 125(6): 1977 - 1979.
[Full Text] [PDF]


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J. Thorac. Cardiovasc. Surg.Home page
R. B. Schuessler
Do we need a map to get through the maze?
J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 627 - 628.
[Full Text] [PDF]




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