HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pastorino, U. Articles by Fazio, F. Search for Related Content PubMed PubMed Citation Articles by Pastorino, U. Articles by Fazio, F. Related Collections Lung - other

J Thorac Cardiovasc Surg 2003;126:1906-1910
© 2003 The American Association for Thoracic Surgery

General thoracic surgery

Fluorodeoxyglucose positron emission tomography improves preoperative staging of resectable lung metastasis

^a Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
^b Department of Thoracic Surgery, European Institute of Oncology Milan, Italy
^c INB CNR, University of Milano Bicocca, Milan, Italy
^d Division of Statistic, European Institute of Oncology, Milan, Italy
^e Department of Pathology, European Institute of Oncology, Milan, Italy
^f Division of Radiology, European Institute of Oncology, Milan, Italy

Received for publication June 22, 2002; revisions received November 27, 2002; accepted for publication January 22, 2003.

^* Address for reprints: Ugo Pastorino, MD, Department of Thoracic Surgery, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
ugo.pastorino{at}istitutotumori.mi.it

OBJECTIVE: F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is now a procedure of proven clinical value in the staging of primary lung cancer. This study evaluated the role of PET in the preoperative assessment of resectable lung metastases.

METHODS: Eighty-six patients with previously treated malignancy and proven or suspected lung metastases, deemed resectable at computed tomography scan, were investigated with 89 preoperative PET procedures. Primary tumor sites were: gastrointestinal in 32 cases, sarcoma in 13, urologic in 14, breast in 8, head and neck in 7, gynecologic in 5, thymus in 5, other in 5. Seventy lung resections were performed in 68 patients of whom only 54 proved to be lung metastasis, 7 were primary lung tumors, and 9 were benign lesions.

RESULTS: In 19 cases (21%) lung surgery was excluded on the basis of PET scan results due to extrapulmonary metastases (11 cases), primary site recurrence (2), mediastinal adenopathy (2), or benign disease (4). All mediastinal node metastases (7 cases) were detected by PET with a sensitivity, accuracy, and negative predictive value for mediastinal staging of 100%, 96%, and 100%, respectively, versus 71%, 92%, and 95% of the computed tomography scan. In the group of patients who underwent lung resection, PET sensitivity for detection of lung metastasis was 87%.

CONCLUSIONS: PET scan proved to be a valuable staging procedure in patients with clinically resectable lung metastasis and changed the therapeutic management in a high proportion of cases.

This article has been cited by other articles:

				Y. Tanaka, Y. Maniwa, W. Nishio, M. Yoshimura, and Y. Okita The optimal timing to resect pulmonary metastasis Eur. J. Cardiothorac. Surg., June 1, 2008; 33(6): 1135 - 1138. [Abstract] [Full Text] [PDF]

				J. Pfannschmidt, H. Dienemann, and H. Hoffmann Surgical Resection of Pulmonary Metastases From Colorectal Cancer: A Systematic Review of Published Series Ann. Thorac. Surg., July 1, 2007; 84(1): 324 - 338. [Abstract] [Full Text] [PDF]

				G. Veronesi, F. Petrella, F. Leo, P. Solli, P. Maissoneuve, D. Galetta, R. Gasparri, G. Pelosi, T. De Pas, and L. Spaggiari Prognostic role of lymph node involvement in lung metastasectomy J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 967 - 972. [Abstract] [Full Text] [PDF]