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J Thorac Cardiovasc Surg 2003;126:2044-2051
© 2003 The American Association for Thoracic Surgery

Surgery for acquired cardiovascular disease

Gender profiling in coronary artery bypass grafting

^a Department of Cardiothoracic Anesthesia (G-3), Cleveland, Ohio, USA
^b Department of Biostatistics, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
^c Department of Anesthesia, Texas Heart Institute, Houston, Tex, USA
^d Department of Thoracic and Cardiac Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

Received for publication April 16, 2003; revisions received June 4, 2003; accepted for publication June 13, 2003.

^* Address for reprints: Colleen Gorman Koch, MD, MS, Department of Cardiothoracic Anesthesia (G-3), The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
kochc{at}ccf.org

OBJECTIVE: Although women are reported to be at increased risk of poor outcome after coronary artery bypass grafting, female gender may simply be a marker of a high-risk profile. Therefore, the objective of this study was to characterize the difference between the female and male profiles of patients presenting for coronary artery bypass grafting.

METHODS: From January 1993 to June 2002, 15,597 patients underwent isolated coronary artery bypass grafting at a single institution. Multivariable logistic regression was used to develop a model of female gender.

RESULTS: Of 15,597 patients, 3596 (23%) were women. Eighteen variables were predictive of the female gender profile, including shorter stature, increased weight, more hypertension, insulin-treated diabetes mellitus, heart failure, and higher triglyceride and high-density lipoprotein cholesterol levels. Hematocrit, bilirubin, and creatinine values were lower in women compared with men.

CONCLUSIONS: The preoperative profiles of women and men undergoing coronary artery bypass grafting are dissimilar. Statistical modeling techniques provide a unique perspective on the preoperative profile of the female patient, who is known to be at a higher risk undergoing coronary artery bypass grafting.

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