HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Richard J. Battafarano Seth D. Force Bryan F. Meyers Jennifer Bell Tracey J. Guthrie Joel D. Cooper G. Alexander Patterson Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Battafarano, R. J. Articles by Patterson, G. A. Search for Related Content PubMed PubMed Citation Articles by Battafarano, R. J. Articles by Patterson, G. A. Related Collections Lung - cancer Related Article

J Thorac Cardiovasc Surg 2004;127:836-842
© 2004 The American Association for Thoracic Surgery

General thoracic surgery

Benefits of resection for metachronous lung cancer

^a Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Mo, USA

Read at the Eighty-third Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 4-7, 2003.

Received for publication May 2, 2003; revisions received August 4, 2003; accepted for publication August 11, 2003.

^* Address for reprints: Richard J. Battafarano, MD, PhD, One Barnes-Jewish Plaza, 3107 Queeny Tower, St Louis, MO 63110-1013, USA
battafarano{at}msnotes.wustl.edu

OBJECTIVES: The benefits of resection for metachronous lung cancer are not well described. The objective of this study was to evaluate the safety and efficacy of surgical resection for metachronous lung cancers.

METHODS: We reviewed the charts of all patients who underwent a second resection for a metachronous lung cancer from July 1, 1988, to December 31, 2002. Type of resection, operative morbidity, mortality, and survival by stage were analyzed. Survival was determined by using the Kaplan-Meier survival method. All patients were pathologically staged by using the 1997 American Joint Committee on Cancer standards.

RESULTS: Pulmonary resections were performed in 69 patients who had undergone a previous resection. The mean interval between the first and second resection was 2.4 ± 2.5 years. Seventy-three percent of patients presented with stage I cancers, 9% with stage II cancers, and 17% with stage III cancers. Lobectomy and wedge resection were performed with equal frequency (42% each) for the metachronous cancers. Operative mortality for the second resection was 5.8%. The mean follow-up after the second resection was 37 months. Overall 5-year actuarial survival for the entire group after the second resection was 33.4%.

CONCLUSIONS: Operations for metachronous cancers provided survival that approximated the expected survival for lung cancer. Surgical intervention should be considered as a safe and effective treatment for resectable metachronous lung cancer in patients with adequate physiologic pulmonary reserve.

This article has been cited by other articles:

				J. Rubins, M. Unger, and G. L. Colice Follow-up and Surveillance of the Lung Cancer Patient Following Curative Intent Therapy: ACCP Evidence-Based Clinical Practice Guideline (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 355S - 367S. [Abstract] [Full Text] [PDF]

				H. Sugimura, F. C. Nichols, P. Yang, M. S. Allen, S. D. Cassivi, C. Deschamps, B. A. Williams, and P. C. Pairolero Survival After Recurrent Nonsmall-Cell Lung Cancer After Complete Pulmonary Resection Ann. Thorac. Surg., February 1, 2007; 83(2): 409 - 418. [Abstract] [Full Text] [PDF]

				P. A. Linden, B. Y. Yeap, M. Y. Chang, W. G. Henderson, M. T. Jaklitsch, S. Khuri, D. J. Sugarbaker, and R. Bueno Morbidity of Lung Resection After Prior Lobectomy: Results from the Veterans Affairs National Surgical Quality Improvement Program Ann. Thorac. Surg., February 1, 2007; 83(2): 425 - 432. [Abstract] [Full Text] [PDF]

				T. Hishida, K. Nagai, J. Yoshida, M. Nishimura, G.-i. Ishii, M. Iwasaki, and Y. Nishiwaki Is surgical resection indicated for a solitary non-small cell lung cancer recurrence? J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 838 - 842. [Abstract] [Full Text] [PDF]

				R. F. Munden, S. S. Swisher, C. W. Stevens, and D. J. Stewart Imaging of the Patient with Non-Small Cell Lung Cancer Radiology, December 1, 2005; 237(3): 803 - 818. [Abstract] [Full Text] [PDF]

				M. S. Kent, P. Korn, J. L. Port, P. C. Lee, N. K. Altorki, and R. J. Korst Cost Effectiveness of Chest Computed Tomography After Lung Cancer Resection: A Decision Analysis Model Ann. Thorac. Surg., October 1, 2005; 80(4): 1215 - 1223. [Abstract] [Full Text] [PDF]

				T. W. Geurts, P. M. Nederlof, M. W.M. van den Brekel, L. J. van't Veer, D. de Jong, A. A.M. Hart, N. van Zandwijk, H. Klomp, A. J.M. Balm, and M.-L. F. van Velthuysen Pulmonary Squamous Cell Carcinoma following Head and Neck Squamous Cell Carcinoma: Metastasis or Second Primary? Clin. Cancer Res., September 15, 2005; 11(18): 6608 - 6614. [Abstract] [Full Text] [PDF]

				V. Patel and J. B. Shrager Which Patients with Stage III Non-Small Cell Lung Cancer Should Undergo Surgical Resection? Oncologist, May 1, 2005; 10(5): 335 - 344. [Abstract] [Full Text] [PDF]

				S. G. Talbot, C. Estilo, E. Maghami, I. S. Sarkaria, D. K. Pham, P. O-charoenrat, N. D. Socci, I. Ngai, D. Carlson, R. Ghossein, et al. Gene Expression Profiling Allows Distinction between Primary and Metastatic Squamous Cell Carcinomas in the Lung Cancer Res., April 15, 2005; 65(8): 3063 - 3071. [Abstract] [Full Text] [PDF]

				R. J. Korst, H. T. Gold, M. S. Kent, J. L. Port, P. C. Lee, and N. K. Altorki Surveillance computed tomography after complete resection for non-small cell lung cancer: Results and costs J. Thorac. Cardiovasc. Surg., March 1, 2005; 129(3): 652 - 660. [Abstract] [Full Text] [PDF]