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Right arrow Trachea and bronchi

J Thorac Cardiovasc Surg 2004;127:877-884
© 2004 The American Association for Thoracic Surgery

General thoracic surgery

Experimental study of a new tracheal prosthesis: Pored Dacron tube

Hisashi Tsukada, MD*,a, Hiroaki Osada, MD, PhDa

a St Marianna University School of Medicine, Department of Surgery, Division of Chest Surgery, Kawasaki, Japan

Received for publication April 14, 2003; revisions received June 12, 2003; revisions received June 26, 2003; accepted for publication July 17, 2003.

* Address for reprints: Hisashi Tsukada, MD, St Marianna University School of Medicine, Department of Surgery, Division of Chest Surgery, 2-16-1 Sugao Miyamae-ku, Kawasaki , Japan
h2tukada{at}marianna-u.ac.jp

OBJECTIVE: This study was designed to evaluate how various sizes and densities of pores in Dacron tubing might enhance its utility as a tracheal prosthesis.

METHODS: A vascular prosthesis made of knitted external velour polyester was prepared for pore formation with a laser. The first set compared different pore sizes (300, 500, and 700 µm) and pore densities (25/cm2 or 100/cm2). Grafts were reinforced with an externally heat-sealed silicone ring. The second set tested grafts with a pore density of 64/cm2 and a pore size of 500 µm internally reinforced with a stainless-steel spiral stent. In all experiments, a canine mediastinal trachea 10 cartilage rings in length was resected, and the prosthesis was then implanted with an omental flap.

RESULTS: Lower pore size and density (300 µm, 25 pores/cm2) led to essentially no tissue ingrowth. Larger pore size (700 µm) and low density (25 pores/cm2) led to rapid and excessive ingrowth of granulation. Midrange pore size (500 µm) and high density (100 pores/cm2) invited steady tissue ingrowth, but marked luminal stenosis eventually developed. Stent-reinforced prostheses with 500-µm pores at 64 pores/cm2, as used in the second set, maintained an average patency rate of 60% or more (range, 20%-100%) at least 12 months after implantation.

CONCLUSION: Our data show that porosity is a key factor for tissue growth through our Dacron tracheal prostheses. This artificial trachea model has led to long-term survivors up to 27 months after the operation and seems promising as a basic model for clinical tracheal repair.




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H. Tsukada, S. Matsuda, H. Inoue, Y. Ikada, and H. Osada
Comparison of bioabsorbable materials for use in artificial tracheal grafts
Interactive CardioVascular and Thoracic Surgery, February 1, 2009; 8(2): 225 - 229.
[Abstract] [Full Text] [PDF]


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