JTCS Speed Up Your Browser
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Masayoshi Inoue
Noriyoshi Sawabata
Shin-ichi Takeda
Hajime Maeda
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Inoue, M.
Right arrow Articles by Maeda, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Inoue, M.
Right arrow Articles by Maeda, H.
Related Collections
Right arrow Lung - cancer

J Thorac Cardiovasc Surg 2004;127:1100-1106
© 2004 The American Association for Thoracic Surgery

General thoracic surgery

Results of surgical intervention for p-stage IIIA (N2) non–small cell lung cancer: Acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe

Masayoshi Inoue, MD, PhDa,*, Noriyoshi Sawabata, MD, PhDa, Shin-ichi Takeda, MD, PhDa, Mitsunori Ohta, MD, PhDb, Yuko Ohno, PhDc, Hajime Maeda, MD, PhDa

a Department of Thoracic Surgery, Toneyama National Hospital, Osaka, Japan
b Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan,
c Department of Mathematical Health Science, Osaka University Graduate School of Medicine, Osaka, Japan

Received for publication June 26, 2003; revisions received August 14, 2003; accepted for publication September 9, 2003.

* Address for reprints: Masayoshi Inoue, MD, Department of Surgery, Toneyama National Hospital, Toneyama 5-1-1, Toyonaka-city 560-8552, Osaka, Japan
masayoshinoue{at}hotmail.com

OBJECTIVES: Non–small cell lung cancer with mediastinal lymph node involvement is a heterogeneous entity different from single mediastinal lymph node metastasis to multiple nodes or extranodal disease. The objective of this study was to identify the subpopulation of patients with N2 disease who can benefit from surgical intervention.

METHODS: We reviewed 219 consecutive patients with N2 non–small cell lung cancer treated with a thoracotomy between November 1980 and June 2002 and retrospectively analyzed 154 of those who had p-stage IIIA disease and underwent a complete resection. Age, sex, side (right or left), histology, location (upper or middle-lower lobe), tumor size, c-N factor, and N2 level (single or multiple) were used as prognostic variables.

RESULTS: The 3- and 5-year survivals were 45.3% and 28.1%, respectively, in patients with p-stage IIIA (N2) disease. Survival for those with single N2 non–small cell lung cancer was significantly better than in those with multiple N2 disease (P = .0001), and patients with a tumor in the upper lobe showed a significantly longer survival than those with middle-lower lobe involvement (P = .0467). The 3- and 5-year survivals for patients with single N2 disease with a primary tumor in the upper lobe were 74.9% and 53.5%, respectively. A multivariate analysis with Cox regression identified 5 predictors of better prognosis: younger age, squamous cell carcinoma as determined by histology, primary tumor location in the upper lobe, c-N0 status, and a single station of mediastinal node metastasis.

CONCLUSION: Our results suggest that of the heterogeneity of N2 diseases, patients with single N2 disease with non–small cell lung cancer in the upper lobe are good candidates for pulmonary resection.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
P. Misthos, E. Sepsas, J. Kokotsakis, I. Skottis, and A. Lioulias
The Significance of One-Station N2 Disease in the Prognosis of Patients With Nonsmall-Cell Lung Cancer
Ann. Thorac. Surg., November 1, 2008; 86(5): 1626 - 1630.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio and A. S. Bryant
Survival of Patients With Unsuspected N2 (Stage IIIA) Nonsmall-Cell Lung Cancer
Ann. Thorac. Surg., August 1, 2008; 86(2): 362 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Z. Mansour, E. A. Kochetkova, N. Santelmo, X. Ducrocq, E. Quoix, J.-M. Wihlm, and G. Massard
Persistent N2 Disease After Induction Therapy Does Not Jeopardize Early and Medium Term Outcomes of Pneumonectomy
Ann. Thorac. Surg., July 1, 2008; 86(1): 228 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio, A. S. Bryant, and M. A. Eloubeidi
Accessing the Aortopulmonary Window (#5) and the Paraaortic (#6) Lymph Nodes in Patients With Non-Small Cell Lung Cancer
Ann. Thorac. Surg., September 1, 2007; 84(3): 940 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Shiono, M. Okumura, N. Sawabata, T. Utsumi, M. Inoue, M. Minami, N. Tomiyama, H. Matsuda, and Y. Sawa
Virtual Mediastinoscopy for Safer and More Accurate Mediastinal Exploration
Ann. Thorac. Surg., September 1, 2007; 84(3): 995 - 999.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
T. Okamoto, R. Maruyama, R. Suemitsu, Y. Aoki, H. Wataya, M. Kojo, and Y. Ichinose
Prognostic value of the histological subtype in completely resected non-small cell lung cancer
Interactive CardioVascular and Thoracic Surgery, August 1, 2006; 5(4): 362 - 366.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
S.-i. Takeda, H. Maeda, T. Okada, T. Yamaguchi, M. Nakagawa, S. Yokota, N. Sawabata, and M. Ohta
Results of pulmonary resection following neoadjuvant therapy for locally advanced (IIIA-IIIB) lung cancer.
Eur. J. Cardiothorac. Surg., July 1, 2006; 30(1): 184 - 189.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Cerfolio and A. S. Bryant
Distribution and Likelihood of Lymph Node Metastasis Based on the Lobar Location of Nonsmall-Cell Lung Cancer
Ann. Thorac. Surg., June 1, 2006; 81(6): 1969 - 1973.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
R. J. Battafarano
Optimal management of patients with non-small cell lung cancer with ipsilateral mediastinal lymph node metastases
J. Thorac. Cardiovasc. Surg., June 1, 2006; 131(6): 1227 - 1228.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Sakao, H. Miyamoto, A. Yamazaki, T. Oh, R. Fukai, K. Shiomi, and Y. Saito
Prognostic Significance of Metastasis to the Highest Mediastinal Lymph Node in Nonsmall Cell Lung Cancer
Ann. Thorac. Surg., January 1, 2006; 81(1): 292 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
L. W. Martin, A. M. Correa, W. Hofstetter, W. K. Hong, R. Komaki, J. B. Putnam Jr, D. C. Rice, W. R. Smythe, S. G. Swisher, A. A. Vaporciyan, et al.
The evolution of treatment outcomes for resected stage IIIA non-small cell lung cancer over 16 years at a single institution
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1601 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
A. Iwasaki, T. Shirakusa, S. Enatsu, S. Maekawa, Y. Yoshinaga, S. Yoneda, and S. Hoshino
Is T2 non-small cell lung cancer located in left lower lobe appropriate to upstage?
Interactive CardioVascular and Thoracic Surgery, April 1, 2005; 4(2): 126 - 129.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2004 by The American Association for Thoracic Surgery.