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J Thorac Cardiovasc Surg 2004;127:1608-1615
© 2004 The American Association for Thoracic Surgery

Surgery for acquired cardiovascular disease

Development of biologic coronary artery bypass grafting in a rabbit model: Revival of a classic concept with modern biotechnology

^a Department of Cardiovascular Surgery, the Graduate School of Medicine, Kyoto University, Kyoto, Japan
^b Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
^c Hayama Heart Center, Kanagawa, Japan

Read at the Eighty-third Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 4-7, 2003.

Received for publication May 19, 2003; revisions received August 8, 2003; revisions received August 11, 2003; accepted for publication September 17, 2003.

^* Address for reprints: Masashi Komeda, MD, PhD, Professor of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Sakyo-Ku, Kyoto, Japan PO: 606-8507
masakom{at}kuhp.kyoto-u.ac.jp

OBJECTIVE: We have developed a technique for biologic coronary artery bypass grafting, which is a revival of a classic concept with modern biotechnology.

METHODS: Acute myocardial infarction was created by ligating the major branch of the circumflex artery in rabbits. Animals were divided into four groups: a nontreated group (group N), a group in which omentum was used to wrap the infarcted area (group G), a group in which a gelatin hydrogel sheet incorporating 100 µg basic fibroblast growth factor was placed over the infarcted area (group F), and a group in which the infarcted area was similarly treated with basic fibroblast growth factor followed by omental wrapping (group FG). Cardiac function was subsequently assessed by echocardiography. Postmortem angiography through the gastroepiploic artery was done in groups G and FG. Infarct size and arteriolar density were evaluated.

RESULTS: Group FG showed a better fractional area change than did the other groups (group N P < .001, group G P = .002, group F P < .001). Angiography revealed that communication from the gastroepiploic artery to the coronary artery was created through a rich bed of neovascularization in all 7 animals of group FG, whereas poor collaterals were recognized in only 2 of 7 animals in group G. Infarct size was reduced to a greater extent in group FG than in groups F, G, and N (10% ± 3%, 16% ± 5%, 19% ± 7%, 23% ± 2%, respectively, group F P = .04, groups G and N P < .01). The number of arterioles 20 to 100 µm in diameter was increased to a greater extent in group FG than in groups F, G, and N (23 ± 5 arterioles/mm², 14 ± 3 arterioles/mm², 10 ± 1 arterioles/mm², 4 ± 2 arterioles/mm², respectively), with the differences being significant.

CONCLUSIONS: These results show that bypass from the gastroepiploic artery to coronary arteries can be achieved without surgical anastomosis through slow release of basic fibroblast growth factor in this rabbit acute myocardial infarction model. This new revascularization concept, biologic coronary artery bypass grafting, could be applicable for revascularizing many tiny coronary vessels in patients who are difficult to treat with conventional surgery or catheter intervention.

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