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J Thorac Cardiovasc Surg 2004;127:1670-1677
© 2004 The American Association for Thoracic Surgery
Surgery for congenital heart disease |
a Department of Anesthesiology, Rochester, Minnesota, USA
b Division of Cardiovascular Surgery, Rochester, Minnesota, USA
c Department of Surgery, Rochester, Minnesota, USA
d Division of Biostatistics, Rochester, Minnesota, USA
e Department of Hematology Research, Mayo Foundation, Rochester, Minn, USA
Received for publication June 24, 2003; revisions received September 26, 2003; accepted for publication October 7, 2003.
* Address for reprints: William C. Oliver, Jr, MD, Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
oliver.william{at}mayo.edu
OBJECTIVES: Infants and children undergoing cardiopulmonary bypass for repair of congenital heart defects are at substantial risk for excessive bleeding, contributing greatly to morbidity and mortality. Aprotinin significantly reduces bleeding and transfusion requirements in adults but is of indeterminate value for pediatric patients. The aim of this study was to determine plasma aprotinin concentrations in these patients with a functional aprotinin assay.
METHODS: Thirty patients less than 16 years of age scheduled for cardiac surgery with aprotinin were enrolled. Aprotinin was administered as a 25,000 KIU/kg bolus, 35,000 KIU/kg cardiopulmonary bypass prime, and 12,500 KIU · kg–1 · h–1 continuous infusion. Blood samples for aprotinin concentrations (kallikrein-inhibiting units/milliliter) were obtained before aprotinin; 5 minutes post-bolus; 5 minutes after cardiopulmonary bypass initiation; 30 and 60 minutes on cardiopulmonary bypass; on discontinuation of aprotinin; 1 hour after aprotinin discontinuation; and 4 hours after permanent separation from cardiopulmonary bypass. For analysis, patients were grouped according to weight (<10 kg, 10-20 kg, >20 kg). Differences between weight groups were assessed using an exact test for categoric variables and 1-way analysis of variance for continuous variables.
RESULTS: Aprotinin concentrations differed significantly across weight groups. Five minutes after aprotinin bolus and initiation of cardiopulmonary bypass, there was significant correlation between weight and aprotinin concentration (r = .57, P = .003; r = .69, P = .001, respectively).
CONCLUSION: A functional assay reveals significant variability in aprotinin concentration for pediatric patients using current weight-based aprotinin dosing. Additional investigation is necessary to determine target aprotinin concentration dosing regimens to provide better efficacy.
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