| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 2004;128:124-129
© 2004 The American Association for Thoracic Surgery
General thoracic surgery |
a Department of Thoracic Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea
b Department of Biomedical Engineering, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea,
c Department of Pulmonary Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea
Read at the Eighty-third Annual Meeting of The American Association for Thoracic Surgery, Boston, Mass, May 4–7, 2003.
Received for publication April 30, 2003; revisions received August 29, 2003; accepted for publication September 30, 2003.
* Address for reprints: Jhingook Kim, MD, Department of Thoracic Surgery, Samsung Medical Center, School of Medicine, Sungkyunkwan University, 50 IL Won-Dong, Kangnam-Ku, Seoul 135-710, South Korea
jkim{at}smc.samsung.co.kr
OBJECTIVES: The major problems in the development of tracheal prosthesis are anastomotic dehiscence and stenosis, caused by poor epithelialization of the prosthetic graft. We developed a novel tracheal prosthesis with viable mucosa transplanted from the oral cavity and reported excellent long-term results after thoracic tracheal replacements in dogs. In the current study, we used tissue-engineering techniques to construct a mucosal prosthetic lining from skin cells and evaluated its usefulness in tracheal replacement.
METHODS: Abdominal skin patches (5 x 10 cm) were harvested from 10 adult mongrel dogs. The epithelial cells were separated, cultured in vitro for 4 weeks, and then seeded onto a porous polylactic glycolic acid scaffold (6 x 8 cm) to construct a lining mucosa. This was then mounted onto the prosthesis framework, made with polypropylene mesh reinforced with polypropylene rings. The mucosa-lined prosthesis was wrapped with the greater omentum of the same dog and placed in the peritoneal cavity for 1 week. Complete surgical resection and replacement of a thoracic tracheal segment (5 cm in length, just above the carina) was then performed using the prosthesis.
RESULTS: The animals regained full activity and survived with normal activity. Bronchoscopy at 1 week and at 1 and 2 months revealed no stenosis in the anastomosis.
CONCLUSIONS: This highly biocompatible tracheal prosthesis could prove useful for the reconstruction of large, circumferential tracheal defects.
This article has been cited by other articles:
|
|
 |
|
  D. Fabre, S. Singhal, V. De Montpreville, B. Decante, S. Mussot, O. Chataigner, O. Mercier, F. Kolb, P. G. Dartevelle, and E. Fadel Composite cervical skin and cartilage flap provides a novel large airway substitute after long-segment tracheal resection J. Thorac. Cardiovasc. Surg., July 1, 2009; 138(1): 32 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Moharamzadeh, I.M. Brook, R. Van Noort, A.M. Scutt, and M.H. Thornhill Tissue-engineered Oral Mucosa: a Review of the Scientific Literature Journal of Dental Research, February 1, 2007; 86(2): 115 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Tan, R. Steiner, S. P. Hoerstrup, and W. Weder Tissue-engineered trachea: History, problems and the future Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 782 - 786. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
