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J Thorac Cardiovasc Surg 2004;128:391-395
© 2004 The American Association for Thoracic Surgery

Cardiopulmonary support and physiology

Improved myocardial function after transmyocardial laser revascularization according to cine magnetic resonance in a porcine model

^a Cardiovascular MRI Core Lab, Department of Radiology, University of Minnesota Medical School, Minneapolis, Minn, USA
^b Heart and Lung Institute Wisconsin, Milwaukee, Wis, USA
^c Department of Radiology, University of Florida Jacksonville, Jacksonville, Fla, USA

Received for publication October 18, 2003; revisions received November 28, 2003; accepted for publication January 21, 2004.

^* Address for reprints: Olaf M. Mühling, MD, I. Medical Hospital and Clinics, Grosshadern Campus, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Olaf.Muehling{at}med.uni-muenchen.de

OBJECTIVE: This study was undertaken to demonstrate that transmyocardial laser revascularization of hypoperfused myocardium improves regional and global myocardial function.

METHODS: Cine magnetic resonance imaging was used to monitor regional wall thickening (in millimeters) and cardiac output (in milliliters per kilogram per minute). Cine magnetic resonance imaging was performed before and 8 weeks after transmyocardial laser revascularization was applied to the hypoperfused lateral wall of the left ventricle (target area) in a porcine model (n = 9, transmyocardial laser revascularization group). A second group of animals was left untreated (n = 8, control group).

RESULTS: Regional wall thickening in the target area improved after transmyocardial laser revascularization (0.7 ± 0.3 mm to 3.7 ± 1.9 mm, P < .02) and was significantly higher (P < .01) after transmyocardial laser revascularization than in the control group, in which it did not improve (0.5 ± 0.6 mm to 0.5 ± 1.2 mm). Accordingly, cardiac output and microsphere-derived myocardial blood flows were significantly higher than in the control group (P < .01), and the amount of triphenyltetrazolium chloride–stained myocardium was lower (P < .01).

CONCLUSION: Cine magnetic resonance imaging demonstrates improved global and regional myocardial function after transmyocardial laser revascularization in a porcine model.

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