JTCS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hiran C. Fernando
Rodney J. Landreneau
Percival O. Buenaventura
Neil A. Christie
James D. Luketich
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fernando, H. C.
Right arrow Articles by Luketich, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernando, H. C.
Right arrow Articles by Luketich, J. D.
Related Collections
Right arrow Lung - cancer
Right arrow Minimally invasive surgery

J Thorac Cardiovasc Surg 2005;129:639-644
© 2005 The American Association for Thoracic Surgery

General Thoracic Surgery

Radiofrequency ablation for the treatment of non–small cell lung cancer in marginal surgical candidates

Hiran C. Fernando, MDa, Alberto De Hoyos, MDa, Rodney J. Landreneau, MDa, Sebastian Gilbert, MDa, William E. Gooding, MSb, Percival O. Buenaventura, MDa, Neil A. Christie, MDa, Chandra Belani, MDc, James D. Luketich, MDa,*

a Department of Surgery, Division of Thoracic and Foregut Surgery, University of Pittsburgh Medical Center,
b Department of Biostatistics, University Pittsburgh Cancer Institute,
c Division of Hematology and Oncology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, Pa

Read at the Thirtieth Annual Meeting of The Western Thoracic Surgical Association, Maui, Hawaii, June 23-26, 2004.

Received for publication June 18, 2004; revisions received September 21, 2004; accepted for publication October 8, 2004.

* Address for reprints: James D. Luketich, MD, Professor of Surgery, Chief, Division of Thoracic and Foregut Surgery, UPMC Presbyterian, 200 Lothrop St, Suite C-800, Pittsburgh, PA 15213 (E-mail: luketichjd{at}upmc.edu).

OBJECTIVE: Treatment options for patients with non–small cell lung cancer who are not surgical candidates or who refuse operation are limited. Radiofrequency ablation represents a potential less invasive option for these patients. Our initial experience with radiofrequency ablation for peripheral, primary non–small cell lung cancer is reported.

METHODS: We treated 21 tumors in 18 patients. Median age was 75 (range 58-86) years. Cancer stages were I (n = 9), II (n = 2), III (n = 3), and IV (n = 4). Patients with stage IV disease included 3 with recurrence after previous lobectomies and 1 with a synchronous liver metastasis also treated with radiofrequency ablation. Median tumor diameter was 2.8 cm (range 1.2-4.5 cm). Radiofrequency ablation was delivered by minithoracotomy in 2 cases and by a computed tomography–guided percutaneous approach in 16 patients. Computed tomographic and positron emission tomographic scans were used to evaluate recurrence and radiographic response in ablated nodules.

RESULTS: One postoperative death occurred from pneumonia after open radiofrequency ablation. Median hospital stay was 2.5 days. A chest tube or pigtail catheter was required in 7 patients (38.9%) for procedure-related pneumothoraces. At a median follow-up of 14 months, 15 patients (83.3%) were alive. Local progression occurred in 8 nodules (38.1%). Mean and median progression-free intervals were 16.8 and 18 months, respectively. For stage I cancers, mean progression-free interval was 17.6 months. Median progression-free interval was not reached.

CONCLUSION: This study demonstrates the feasibility of radiofrequency ablation for small, peripheral non–small cell lung cancer tumors. Local control is comparable to, if not better than, that provided by radiotherapy. Radiofrequency ablation should continue to be evaluated by thoracic surgeons as a noninvasive therapy for the high-risk patient with non–small cell lung cancer.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Crabtree, V. Puri, R. Timmerman, H. Fernando, J. Bradley, P. A. Decker, R. Paulus, J. B. Putnum Jr., D. E. Dupuy, and B. Meyers
Treatment of stage I lung cancer in high-risk and inoperable patients: Comparison of prospective clinical trials using stereotactic body radiotherapy (RTOG 0236), sublobar resection (ACOSOG Z4032), and radiofrequency ablation (ACOSOG Z4033)
J. Thorac. Cardiovasc. Surg., March 1, 2013; 145(3): 692 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
S. Renaud, P.-E. Falcoz, A. Olland, and G. Massard
Is radiofrequency ablation or stereotactic ablative radiotherapy the best treatment for radically treatable primary lung cancer unfit for surgery?
Interact CardioVasc Thorac Surg, January 1, 2013; 16(1): 68 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Acta RadiolHome page
H. Schoellnast, A. Deodhar, M. Hsu, C. Moskowitz, S. A. Nehmeh, R. H. Thornton, C. T. Sofocleous, W. Alago Jr, R. J. Downey, C. G. Azzoli, et al.
Recurrent non-small cell lung cancer: evaluation of CT-guided radiofrequency ablation as salvage therapy
Acta Radiologica, October 1, 2012; 53(8): 893 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. P. Wisnivesky, M. Bonomi, L. Lurslurchachai, G. Mhango, and E. A. Halm
Radiotherapy and chemotherapy for elderly patients with stage I-II unresected lung cancer
Eur. Respir. J., October 1, 2012; 40(4): 957 - 964.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
F. G. Abtin, J. Eradat, A. J. Gutierrez, C. Lee, M. C. Fishbein, and R. D. Suh
Radiofrequency Ablation of Lung Tumors: Imaging Features of the Postablation Zone
RadioGraphics, July 1, 2012; 32(4): 947 - 969.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
D. E. Dupuy
Image-guided Thermal Ablation of Lung Malignancies
Radiology, September 1, 2011; 260(3): 633 - 655.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
N. C. Purandare, V. Rangarajan, S. A. Shah, A. R. Sharma, S. S. Kulkarni, A. V. Kulkarni, and S. G. Dua
Therapeutic Response to Radiofrequency Ablation of Neoplastic Lesions: FDG PET/CT Findings
RadioGraphics, January 1, 2011; 31(1): 201 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Pennathur, J. D. Luketich, D. E. Heron, M. J. Schuchert, S. Burton, G. Abbas, W. E. Gooding, P. F. Ferson, C. Ozhasoglu, S. Gilbert, et al.
Stereotactic Radiosurgery for the Treatment of Lung Neoplasm: Experience in 100 Consecutive Patients
Ann. Thorac. Surg., November 1, 2009; 88(5): 1594 - 1600.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Pennathur, G. Abbas, W. E. Gooding, M. J. Schuchert, S. Gilbert, N. A. Christie, R. J. Landreneau, and J. D. Luketich
Image-Guided Radiofrequency Ablation of Lung Neoplasm in 100 Consecutive Patients by a Thoracic Surgical Service
Ann. Thorac. Surg., November 1, 2009; 88(5): 1601 - 1608.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. C. Zhu, T. D. Yan, D. Glenn, and D. L. Morris
Radiofrequency Ablation of Lung Tumors: Feasibility and Safety
Ann. Thorac. Surg., April 1, 2009; 87(4): 1023 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Pennathur, G. Abbas, I. Qureshi, M. J. Schuchert, Y. Wang, S. Gilbert, R. J. Landreneau, and J. D. Luketich
Radiofrequency Ablation for the Treatment of Pulmonary Metastases
Ann. Thorac. Surg., April 1, 2009; 87(4): 1030 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Pennathur, J. D. Luketich, D. E. Heron, G. Abbas, S. Burton, M. Chen, W. E. Gooding, C. Ozhasoglu, R. J. Landreneau, and N. A. Christie
Stereotactic radiosurgery for the treatment of stage I non-small cell lung cancer in high-risk patients
J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 597 - 604.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Schneider, A. Warth, E. Herpel, P. A. Schnabel, A. von Deimling, R. Eberhardt, F. J.F. Herth, H. Dienemann, and H. Hoffmann
Intraoperative Radiofrequency Ablation of Lung Metastases and Histologic Evaluation
Ann. Thorac. Surg., February 1, 2009; 87(2): 379 - 384.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
P. A. Linden, J. O. Wee, M. T. Jaklitsch, and Y. L. Colson
Extending Indications for Radiofrequency Ablation of Lung Tumors Through an Intraoperative Approach
Ann. Thorac. Surg., February 1, 2008; 85(2): 420 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. C. Fernando
Radiofrequency Ablation to Treat Non-Small Cell Lung Cancer and Pulmonary Metastases
Ann. Thorac. Surg., February 1, 2008; 85(2): S780 - S784.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. A. Cesaretti, A. Pennathur, B. S. Rosenstein, S. J. Swanson, and H. C. Fernando
Stereotactic Radiosurgery for Thoracic Malignancies
Ann. Thorac. Surg., February 1, 2008; 85(2): S785 - S791.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
T. Hiraki, H. Gobara, T. Iishi, Y. Sano, T. Iguchi, H. Fujiwara, N. Tajiri, J. Sakurai, H. Date, H. Mimura, et al.
Percutaneous radiofrequency ablation for clinical stage I non-small cell lung cancer: results in 20 nonsurgical candidates.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1306 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Pennathur, J. D. Luketich, G. Abbas, M. Chen, H. C. Fernando, W. E. Gooding, M. J. Schuchert, S. Gilbert, N. A. Christie, and R. J. Landreneau
Radiofrequency ablation for the treatment of stage I non-small cell lung cancer in high-risk patients.
J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 857 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Pennathur, J. D. Luketich, S. Burton, G. Abbas, D. E. Heron, H. C. Fernando, W. E. Gooding, C. Ozhasoglu, J. Ireland, R. J. Landreneau, et al.
Stereotactic Radiosurgery for the Treatment of Lung Neoplasm: Initial Experience
Ann. Thorac. Surg., May 1, 2007; 83(5): 1820 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
S.-Y. Chiou, J.-B. Liu, and L. Needleman
Current Status of Sonographically Guided Radiofrequency Ablation Techniques
J. Ultrasound Med., April 1, 2007; 26(4): 487 - 499.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
L. Thanos, S. Mylona, M. Pomoni, K. Athanassiadi, N. Theakos, L. Zoganas, and N. Batakis
Percutaneous radiofrequency thermal ablation of primary and metastatic lung tumors
Eur J Cardiothorac Surg, November 1, 2006; 30(5): 797 - 800.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Fukuse, E. Ogawa, F. Chen, H. Sakai, and H. Wada
Limited surgery and radiofrequency ablation for recurrent lung cancer.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1506 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. A. Elliott, T. B. Curry, T. D. Atwell, M. J. Brown, and S. H. Rose
Lung isolation, one-lung ventilation, and continuous positive airway pressure with air for radiofrequency ablation of neoplastic pulmonary lesions.
Anesth. Analg., August 1, 2006; 103(2): 463 - 4, table of contents.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. L. Nguyen, W. J. Scott, and M. Goldberg
Radiofrequency Ablation of Lung Malignancies
Ann. Thorac. Surg., July 1, 2006; 82(1): 365 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Cardiothorac SurgHome page
M. C. Ambrogi, M. Lucchi, P. Dini, F. Melfi, G. Fontanini, P. Faviana, O. Fanucchi, and A. Mussi
Percutaneous radiofrequency ablation of lung tumours: results in the mid-term
Eur J Cardiothorac Surg, July 1, 2006; 30(1): 177 - 183.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. C. Ambrogi, G. Fontanini, R. Cioni, P. Faviana, O. Fanucchi, and A. Mussi
Biologic effects of radiofrequency thermal ablation on non-small cell lung cancer: Results of a pilot study
J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1002 - 1006.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2005 by The American Association for Thoracic Surgery.