JTCS Sign the Guestbook
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Pier Luigi Filosso
Enrico Ruffini
Caterina Casadio
Maurizio Mancuso
Davide Turello
Riccardo Carlo Cristofori
Giuliano Maggi
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Filosso, P. L.
Right arrow Articles by Maggi, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Filosso, P. L.
Right arrow Articles by Maggi, G.
Related Collections
Right arrow Lung - cancer

J Thorac Cardiovasc Surg 2005;129:819-824
© 2005 The American Association for Thoracic Surgery

General Thoracic Surgery

Large-cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighteen cases and the efficacy of adjuvant treatment with octreotide

Pier Luigi Filosso, MDa,*, Enrico Ruffini, MDa, Alberto Oliaro, MDa, Ottavio Rena, MDb, Caterina Casadio, MDb, Maurizio Mancuso, MDa, Davide Turello, MDa, Riccardo Carlo Cristofori, MDa, Giuliano Maggi, MDa

a Department of Thoracic Surgery, San Giovanni Battista Hospital, University of Torino, Torino, Italy
b Service of Thoracic Surgery, Amedeo Avogadro University, Novara, Italy

Received for publication January 14, 2004; revisions received April 25, 2004; accepted for publication May 10, 2004.

* Address for reprints: Pier Luigi Filosso, MD, University of Torino Italy, San Giovanni Battista Hospital, Department of Thoracic Surgery, Via Genova, 3 10126 Torino, Italy (E-mail: pierluigifilosso{at}tiscalinet.it).

OBJECTIVE: This study was undertaken to evaluate the efficacy of a new adjuvant protocol with octreotide, alone or in combination with radiotherapy, in radically resected large cell neuroendocrine carcinomas of the lung.

METHODS: Between 1990 and 2001, a total of 18 consecutive patients affected by large cell neuroendocrine carcinomas of the lung were operated on. Lobectomy and systemic lymphadenectomy were performed in all cases. Postoperative radiotherapy was performed when stage was higher than Ib. Ten patients with positive results of preoperative indium In-111 pentetreotide scintigraphy received octreotide after the operation.

RESULTS: Nine patients (50%) had local recurrences or distant metastases (mean recurrence time 14 months); palliative chemotherapy was given, but all patients died. In 10 cases (55.5%) octreotide alone or in combination with radiotherapy was administered as adjuvant treatment; 9 of these patients (90%) are alive and free of disease (P = .0007), and the other had liver and brain metastases 21 months after surgery.

CONCLUSIONS: Our preliminary results seem to demonstrate the efficacy of octreotide as adjuvant therapy in large cell neuroendocrine carcinomas of the lung when results of preoperative indium In-111 pentetreotide scintigraphy were positive. Further study are required to assess the utility of octreotide in patients with negative results of indium In-111 pentetreotide scintigraphy.




This article has been cited by other articles:


Home page
 Am J Clin PatholHome page
C. A. Moran, S. Suster, D. Coppola, and M. R. Wick
Neuroendocrine Carcinomas of the Lung: A Critical Analysis
Am J Clin Pathol, February 1, 2009; 131(2): 206 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Nakatani, and T. Fujisawa
Pulmonary Large Cell Neuroendocrine Carcinoma: Its Place in the Spectrum of Pulmonary Carcinoma
Ann. Thorac. Surg., August 1, 2007; 84(2): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Moriya, Y. Takiguchi, Y. Sekine, K. Shibuya, T. Iizasa, H. Kimura, Y. Nakatani, and T. Fujisawa
Prospective Study of Adjuvant Chemotherapy for Pulmonary Large Cell Neuroendocrine Carcinoma
Ann. Thorac. Surg., November 1, 2006; 82(5): 1802 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Rossi, A. Cavazza, A. Marchioni, L. Longo, M. Migaldi, G. Sartori, N. Bigiani, L. Schirosi, C. Casali, U. Morandi, et al.
Role of Chemotherapy and the Receptor Tyrosine Kinases KIT, PDGFR{alpha}, PDGFR{beta}, and Met in Large-Cell Neuroendocrine Carcinoma of the Lung
J. Clin. Oncol., December 1, 2005; 23(34): 8774 - 8785.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2005 by The American Association for Thoracic Surgery.