JTCS Click here to go to SJM website.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correction (v130,p1445)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ruiz, C. E.
Right arrow Articles by Kiupel, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ruiz, C. E.
Right arrow Articles by Kiupel, M.
Related Collections
Right arrow Valve disease

J Thorac Cardiovasc Surg 2005;130:477-484
© 2005 The American Association for Thoracic Surgery

Evolving Technology

Transcatheter placement of a low-profile biodegradable pulmonary valve made of small intestinal submucosa: A long-term study in a swine model

Carlos E. Ruiz, MD, PhD a , * , Motofumi Iemura, MD a , Sibyl Medie, MS a , Peter Varga, MD a , William G. Van Alstine, DVM, PhD b , Susan Mack, BA c , Anna Deligio, CRT a , Neal Fearnot, PhD c , Ulf H. Beier, MD, PhD a , Dusan Pavcnik, MD, PhD d , Ziyad M. Hijazi, MD e , Matti Kiupel, DVM, PhD f

a Division of Pediatric Cardiology, Department of Pediatrics, University of Illinois at Chicago, Chicago, Ill
b Purdue University, West Lafayette, Ind
c Medical Institute, West Lafayette, Ind
d Dotter Interventional Institute, Oregon Health Sciences University, Portland, Ore
e Division of Pediatric Cardiology, University of Chicago, Children’s Hospital, Chicago, Ill
f College of Veterinary Medicine, Michigan State University, East Lansing, Mich.

Received for publication November 19, 2004; revisions received February 3, 2005; accepted for publication April 14, 2005.

* Address for reprints: Carlos E. Ruiz, MD, PhD, Division of Pediatric Cardiology, University of Illinois at Chicago, 840 S Wood St (Rm 1250), Chicago, IL 60612. (Email: cruizmd{at}uic.edu).

OBJECTIVE: We sought to investigate a placement of a percutaneous low-profile prosthetic valve constructed of small intestinal submucosa in the pulmonary position in a swine model.

METHODS: Twelve female farm pigs were stented at the native pulmonary valve to induce pulmonary insufficiency. Once right ventricular dilation occurred, the small intestinal submucosa valve was implanted. The pigs were followed up with transthoracic echocardiographic Doppler scanning. One animal died of heart failure before valve replacement. Animals were euthanized at 1 day, 1 month, 3 months, 6 months, and 12 months after valve implantation.

RESULTS: The small intestinal submucosa pulmonary valve showed effective reversal of pulmonary regurgitation. There were no misplacements during deployment. There were no embolizations. One-year echocardiographic follow-up showed minimal regurgitation and no stenosis for a valve/vessel ratio of 0.78 or greater. Histologic examination demonstrated intensive remodeling of the small intestinal submucosal valve. Within 1 month, the surface was covered by endothelium, and fibroblasts invaded the interior. Over the following months, the small intestinal submucosal valve remodeled without apparent graft rejection.

CONCLUSION: The small intestinal submucosa valve has the potential for graft longevity without the need for anticoagulation or immunosuppression. Histologic remodeling of the valve tissue provides a replacement capable of resembling a native valve that can be placed percutaneously with low-profile delivery systems.




This article has been cited by other articles:


Home page
 Phil Trans R Soc BHome page
P. M Taylor
Biological matrices and bionanotechnology
Phil Trans R Soc B, August 29, 2007; 362(1484): 1313 - 1320.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Attmann, R. Quaden, T. Jahnke, S. Muller-Hulsbeck, A. Boening, J. Cremer, and G. Lutter
Percutaneous Pulmonary Valve Replacement: 3-Month Evaluation of Self-Expanding Valved Stents
Ann. Thorac. Surg., August 1, 2006; 82(2): 708 - 713.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
U.A. Stock, I. Degenkolbe, T. Attmann, K. Schenke-Layland, S. Freitag, and G. Lutter
Prevention of device-related tissue damage during percutaneous deployment of tissue-engineered heart valves
J. Thorac. Cardiovasc. Surg., June 1, 2006; 131(6): 1323 - 1330.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2005 by The American Association for Thoracic Surgery.