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J Thorac Cardiovasc Surg 2005;130:485-490
© 2005 The American Association for Thoracic Surgery


Surgery for Acquired Cardiovascular Disease

Risk factors for late stroke after coronary artery bypass grafting

Thomas Schachner, MD * , Anne Zimmer, Georg Nagele, MD, Guenther Laufer, MD, Johannes Bonatti, MD

Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria.

Received for publication November 8, 2004; revisions received December 6, 2004; accepted for publication December 23, 2004.

* Address for reprints: Thomas Schachner, MD, Innsbruck Medical University, Department of Cardiac Surgery, Innsbruck, Austria. (Email: Thomas.Schachner{at}uibk.ac.at).

BACKGROUND: Postoperative stroke is a severe complication immediately after coronary artery bypass grafting, and it significantly deteriorates the postoperative quality of life if it occurs in the long term. It was the aim of our study to determine factors associated with the occurrence of new strokes during long-term follow-up after coronary artery bypass grafting.

METHODS: From 387 of 500 patients undergoing coronary artery bypass grafting (age, 67 years [33–84 years]; 76% male) who had intraoperative epiaortic ultrasonography for assessment of ascending aortic wall thickness, a complete follow-up regarding postoperative stroke was achieved. The median follow-up time was 52 months (9–74 months).

RESULTS: A stroke occurred in 26 (7%) of 387 patients, and the cumulative freedom from stroke was 99%, 95%, and 89% after 1, 3, and 5 years, respectively. A significantly lower freedom from stroke was present in patients with an age of 70 years or more (P = .007), preoperative unstable angina (P = .031), chronic obstructive pulmonary disease (P = .009), carotid artery disease (P < .001), preoperative history of neurologic events (P < .001), and a maximum ascending aortic wall thickness of 4 mm or more (P = .010). Multivariate analysis revealed preoperative history of neurologic events (P = .021) to be an independent risk factor.

CONCLUSION: Patients with ascending aortic atherosclerosis, older age (≥70 years), preoperative unstable angina, chronic obstructive pulmonary disease, and carotid artery disease are at risk for late postoperative stroke after coronary artery bypass grafting. A history of neurologic events is of special predictive importance.





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