HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Yoshio Tsunezuka Makoto Oda Go Watanabe Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tamura, M. Articles by Watanabe, G. Search for Related Content PubMed PubMed Citation Articles by Tamura, M. Articles by Watanabe, G.

J Thorac Cardiovasc Surg 2005;130:740-745
© 2005 The American Association for Thoracic Surgery

General Thoracic Surgery

Prognostic significance of dysadherin expression in patients with non–small cell lung cancer

Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.

Received for publication September 29, 2004; revisions received November 29, 2004; accepted for publication December 28, 2004.

^_* Address for reprints: Masaya Tamura, MD, Department of General and Cardiothoracic Surgery, Kanazawa University School of Medicine, Takara-machi 13-1, Kanazawa, 920-8640, Japan (Email: m-tamura{at}sf.m.kanazawa-u.ac.jp).

OBJECTIVE: The aim of this study was to evaluate the expression of dysadherin and E-cadherin and to investigate their clinical significance as prognostic factors in non–small cell lung cancer.

METHODS: Non–small cell lung cancer specimens were obtained from 131 patients undergoing clinically indicated operations at the Department of General and Cardiothoracic Surgery, Kanazawa University Hospital, between 1995 and 1997. All patients had undergone curative resection of the primary tumor, including systematic lymph node dissection. The avidin-biotin-peroxidase complex method was used for immunostaining of dysadherin and E-cadherin.

RESULTS: Among the 131 lung cancer specimens, 46 (35.1%) tumors were positively stained with dysadherin. Preserved membranous E-cadherin staining was present in 45.8% (60/131) of cases. In this analysis dysadherin expression was not correlated with E-cadherin expression (P = .1333), but a significant association was observed between dysadherin expression and survival time. The overall survival of patients with dysadherin-positive tumors was significantly worse than that of those with dysadherin-negative tumors (P = .0059). Patients with reduced E-cadherin immunopositivity survived significantly shorter than those with preserved E-cadherin immunopositivity (P = .0406). The overall survival of patients with positive dysadherin and reduced E-cadherin expression was significantly worse than that of patients with negative dysadherin and preserved E-cadherin expression (P = .0002). Multivariate analysis revealed the independent prognostic value of dysadherin positivity, reduced E-cadherin expression, and lymph node metastasis on overall survival.

CONCLUSIONS: Dysadherin expression is an independent prognostic factor of survival in patients with non–small cell lung cancer, and combined immunohistochemical analysis of dysadherin and E-cadherin expression might provide further prognostic information.

This article has been cited by other articles:

				T. J. Miller and P. B. Davis FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L654 - L664. [Abstract] [Full Text] [PDF]