JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Stefan Fischer
Anna Meyer
Axel Haverich
Martin Strueber
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fischer, S.
Right arrow Articles by Strueber, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fischer, S.
Right arrow Articles by Strueber, M.
Related Collections
Right arrow Lung - transplantation

J Thorac Cardiovasc Surg 2006;131:719-723
© 2006 The American Association for Thoracic Surgery

Cardiothoracic Transplantation

Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung

Stefan Fischer, MD, MSc a , Andre R. Simon, MD a , Tobias Welte, MD b , Marius M. Hoeper, MD b , Anna Meyer, MD a , Rene Tessmann, MD a , Bernhard Gohrbandt, MD a , Jens Gottlieb, MD b , Axel Haverich, MD a , Martin Strueber, MD a , *

a Hannover Thoracic Transplant Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany
b Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany

Received for publication June 27, 2005; revisions received September 22, 2005; accepted for publication October 10, 2005.

* Address for reprints: Martin Strueber, MD, Director, Hannover Thoracic Transplant and Cardiac Assist Program, Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany (Email: strueber{at}thg.mh-hannover.de).

BACKGROUND: Worsening of lung failure in patients awaiting a lung transplantation might lead to ventilation-refractory hypercapnia and respiratory acidosis. Most transplant centers consider pretransplantation extracorporeal membrane oxygenation as a contraindication for lung transplantation because of the poor outcome. We have, for the first time, applied the novel pumpless interventional lung assist NovaLung for bridge to lung transplantation in patients with severe ventilation-refractory hypercapnia. We report on our initial experience.

METHODS: Between March 2003 and March 2005, 176 lung transplantations were performed, of which 60% were high-urgency lung transplantations. Twelve of the high-urgency recipients had severe ventilation-refractory hypercapnia and respiratory acidosis. These patients were connected to the novel pumpless interventional lung assist NovaLung for bridge to lung transplantation.

RESULTS: The length of interventional lung assist NovaLung support was 15 ± 8 days (4-32 days). PaO 2, pH, and PaCO 2 levels in arterial blood prior to interventional lung assist NovaLung implantation were 71 ± 27 mm Hg, 7.121 ± 0.1, and 128 ± 42 mm Hg, respectively. Six hours after interventional lung assist NovaLung implantation, PaO 2, pH, and PaCO 2 levels had changed to 83 ± 17 mm Hg (ns), 7.344 ± 0.1 (P < .05), and 52 ± 5 mm Hg (P < .05), respectively. Four patients died of multiorgan failure, 2 patients before and 2 after lung transplantation. Thus, 10 out of 12 patients were successfully bridged to lung transplantation, and 8 are still alive (1-year survival, 80%).

CONCLUSIONS: This report suggests that interventional lung assist NovaLung implantation is an effective bridge to lung transplantation strategy in patients with ventilation-refractory hypercapnia.

Abbreviations and Acronyms AVCO2R = arteriovenous CO2 removal; ECMO = extracorporeal membrane oxygenation; HU = high urgency; iLA = interventional lung assist NovaLung; LTx = lung transplantation




This article has been cited by other articles:


Home page
 Interact CardioVasc Thorac SurgHome page
J. Reeb, P.-E. Falcoz, N. Santelmo, and G. Massard
Double lumen bi-cava cannula for veno-venous extracorporeal membrane oxygenation as bridge to lung transplantation in non-intubated patient
Interact CardioVasc Thorac Surg, January 1, 2012; 14(1): 125 - 127.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir RevHome page
M. M. Hoeper
"Treat-to-target" in pulmonary arterial hypertension and the use of extracorporeal membrane oxygenation as a bridge to transplantation
Eur. Respir. Rev., December 1, 2011; 20(122): 297 - 300.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. M. Hoeper and J. Granton
Intensive Care Unit Management of Patients with Severe Pulmonary Hypertension and Right Heart Failure
Am. J. Respir. Crit. Care Med., November 15, 2011; 184(10): 1114 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. A. Bermudez, R. V. Rocha, D. Zaldonis, J. K. Bhama, M. M. Crespo, N. Shigemura, J. M. Pilewski, P. L. Sappington, A. J. Boujoukos, and Y. Toyoda
Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplant: Midterm Outcomes
Ann. Thorac. Surg., October 1, 2011; 92(4): 1226 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
W. Bartosik, J. J. Egan, and A. E. Wood
The Novalung interventional lung assist as bridge to lung transplantation for self-ventilating patients - initial experience
Interact CardioVasc Thorac Surg, August 1, 2011; 13(2): 198 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Haneya, A. Philipp, T. Mueller, M. Lubnow, M. Pfeifer, W. Zink, M. Hilker, C. Schmid, and S. Hirt
Extracorporeal Circulatory Systems as a Bridge to Lung Transplantation at Remote Transplant Centers
Ann. Thorac. Surg., January 1, 2011; 91(1): 250 - 255.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. R. Pipeling and E. Fan
Therapies for Refractory Hypoxemia in Acute Respiratory Distress Syndrome
JAMA, December 8, 2010; 304(22): 2521 - 2527.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. M. Hoganson, J. L. Anderson, E. F. Weinberg, E. J. Swart, B. K. Orrick, J. T. Borenstein, and J. P. Vacanti
Branched vascular network architecture: A new approach to lung assist device technology
J. Thorac. Cardiovasc. Surg., November 1, 2010; 140(5): 990 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. Sanchez-Lorente, T. Go, P. Jungebluth, I. Rovira, M. Mata, M. C. Ayats, and P. Macchiarini
Single double-lumen venous-venous pump-driven extracorporeal lung membrane support
J. Thorac. Cardiovasc. Surg., September 1, 2010; 140(3): 558 - 563.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. A. Mangi, D. P. Mason, J. J. Yun, S. C. Murthy, and G. B. Pettersson
Bridge to lung transplantation using short-term ambulatory extracorporeal membrane oxygenation
J. Thorac. Cardiovasc. Surg., September 1, 2010; 140(3): 713 - 715.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
V. Puri, D. Epstein, S. C. Raithel, S. K. Gandhi, S. C. Sweet, A. Faro, and C. B. Huddleston
Extracorporeal membrane oxygenation in pediatric lung transplantation
J. Thorac. Cardiovasc. Surg., August 1, 2010; 140(2): 427 - 432.
[Abstract] [Full Text] [PDF]

Home page
 Lung TransplantationHome page
D. E. M. Van Raemdonck, G. M. Verleden, W. Coosemans, H. Decaluwe, G. Decker, P. De Leyn, P. Nafteux, and T. Lerut
Increasing the donor pool
Lung Transplantation, June 7, 2010; 104 - 127.
[Abstract] [Fulltext] [PDF]

Home page
 Lung TransplantationHome page
F. Meloni and M. Strueber
Early peri-operative care
Lung Transplantation, June 7, 2010; 131 - 146.
[Abstract] [Fulltext] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. P. Mason, L. Thuita, E. R. Nowicki, S. C. Murthy, G. B. Pettersson, and E. H. Blackstone
Should lung transplantation be performed for patients on mechanical respiratory support? The US experience
J. Thorac. Cardiovasc. Surg., March 1, 2010; 139(3): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. L. Huffmyer, K. E. Littlewood, and E. C. Nemergut
Perioperative Management of the Adult with Cystic Fibrosis
Anesth. Analg., December 1, 2009; 109(6): 1949 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 Interact CardioVasc Thorac SurgHome page
A. L. Meyer, M. Strueber, S. Tomaszek, A. Goerler, A. R. Simon, A. Haverich, and S. Fischer
Temporary cardiac support with a mini-circuit system consisting of a centrifugal pump and a membrane ventilator
Interact CardioVasc Thorac Surg, November 1, 2009; 9(5): 780 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K. Taylor and H. Holtby
Emergency Interventional Lung Assist for Pulmonary Hypertension
Anesth. Analg., August 1, 2009; 109(2): 382 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Muller, M. Lubnow, A. Philipp, T. Bein, A. Jeron, A. Luchner, L. Rupprecht, M. Reng, J. Langgartner, C. E. Wrede, et al.
Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy
Eur. Respir. J., March 1, 2009; 33(3): 551 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. M. Hoeper and T. Welte
Extracorporeal lung assist: more than kicking a dead horse?
Eur. Respir. J., December 1, 2008; 32(6): 1431 - 1432.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. Florchinger, A. Philipp, A. Klose, M. Hilker, R. Kobuch, L. Rupprecht, A. Keyser, T. Puhler, S. Hirt, K. Wiebe, et al.
Pumpless Extracorporeal Lung Assist: A 10-Year Institutional Experience
Ann. Thorac. Surg., August 1, 2008; 86(2): 410 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Iglesias, P. Jungebluth, O. Sibila, I. Aldabo, M. P. Matute, C. Petit, A. Torres, and P. Macchiarini
Experimental safety and efficacy evaluation of an extracorporeal pumpless artificial lung in providing respiratory support through the axillary vessels
J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 339 - 345.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.