JTCS Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tomoyuki Hishida
Junji Yoshida
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hishida, T.
Right arrow Articles by Nishiwaki, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hishida, T.
Right arrow Articles by Nishiwaki, Y.
Related Collections
Right arrow Lung - cancer

J Thorac Cardiovasc Surg 2006;131:838-842
© 2006 The American Association for Thoracic Surgery

General Thoracic Surgery

Is surgical resection indicated for a solitary non–small cell lung cancer recurrence?

Tomoyuki Hishida, MD a , * , Kanji Nagai, MD a , Junji Yoshida, MD a , Mitsuyo Nishimura, MD a , Gen-ichiro Ishii, MD b , Motoki Iwasaki, MD c , Yutaka Nishiwaki, MD a

a Department of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan
b Pathology Division, National Cancer Center Research Institute East, Chiba, Japan
c Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

Received for publication September 8, 2005; revisions received November 20, 2005; accepted for publication November 28, 2005.

* Address for reprints: Tomoyuki Hishida, MD, Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577 Japan (Email: thishida{at}nifty.com).

OBJECTIVES: Some investigators have reported long-term survival after surgical resection of a solitary non–small cell lung cancer recurrence in various sites. However, the role and indications of the second operation remain unclear.

METHODS: We reviewed 28 patients with a solitary recurrence after successful initial resection of primary non–small cell lung cancer who underwent resection of the recurrent lesion. The clinicopathologic factors associated with outcome were analyzed.

RESULTS: There were 17 men and 11 women. Recurrence resection was performed for the following sites: 16 in the lung, 5 in the brain, 2 in the adrenal gland, and 1 each in the chest wall, stomach, skin, pelvic lymph node, and malar bone. The median survival time was 25 months, and the 1-, 2-, and 5-year survival rates after recurrence were 89%, 59%, and 32%, respectively. Advanced p-stage (p-stage II and III, n = 14) of the primary tumor was the significant negative prognostic factor. Patients with p-stage II or III had survival equivalent to that of those who had multiple recurrences or were unfit for further surgical intervention.

CONCLUSIONS: Resection of a solitary non–small cell lung cancer recurrence might provide long-term survival in highly selected patients. However, surgical resection might be contraindicated if the primary tumor is stage II or III.

Abbreviations and Acronyms FDG = 18F fluorodeoxyglucose; NSCLC = non–small cell lung cancer; PET = positron emission tomography; RFI = recurrence-free interval






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.