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J Thorac Cardiovasc Surg 2006;132:99-104
© 2006 The American Association for Thoracic Surgery

General Thoracic Surgery

Bronchoscopic treatment of postpneumonectomy bronchopleural fistula with a collagen screw plug

Hiroyuki Tao, MD * , Masato Araki, MD, Toshihiko Sato, MD, Shigeyuki Morino, MD, Rieko Kawanami, MD, Makoto Yoshitani, MD, Tatsuo Nakamura, MD

Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

Received for publication January 1, 2006; revisions received February 20, 2006; accepted for publication February 24, 2006.

* Address for reprints: Hiroyuki Tao, MD, Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. (Email: hiroyukitao{at}hotmail.com).

OBJECTIVE: Bronchopleural fistula is a critical complication that may occur after pulmonary resection. Early closure of the fistula is required to prevent thoracic empyema or aspiration pneumonia. We have designed a novel procedure for bronchoscopic occlusion of the fistula with a collagen screw plug and assessed its feasibility in an experimental animal model.

METHODS: Adult beagle dogs underwent right or left pneumonectomy, and the bronchial stump was closed with the Sweet method. A silicone bar (2 mm in diameter) was then placed in the middle of the bronchial stump. Seven days after the operation, the silicone bar was removed bronchoscopically, and fistula formation was confirmed. A screw-shaped 2% collagen screw plug (20 mm long and 3 mm in diameter) was mounted at the end of a modified endoscopic cannula and then inserted into the fistula. Autologous platelet-rich plasma was then soaked onto the inserted plug.

RESULTS: Nine of 10 beagle dogs with bronchopleural fistula were treated successfully by plug occlusion. One dog died of pneumothorax caused by dislocation of the plug. Pathologic examination revealed that the collagen sponge had been replaced by fibrous tissue and that the fistula was covered with normal epithelium. Although soaking with platelet-rich plasma made the plug airtight immediately, the use of platelet-rich plasma seemed to make no distinct difference with respect to the treatment result or pathologic findings.

CONCLUSION: Bronchoscopic occlusion with a collagen screw plug is a promising option for treatment of small bronchopleural fistulas after pulmonary surgery.

Abbreviations and Acronyms BPF = bronchopleural fistula; PRP = platelet-rich plasma




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