JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Ken Kodama
Noriaki Tsubota
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Okada, M.
Right arrow Articles by Tsubota, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Okada, M.
Right arrow Articles by Tsubota, N.

J Thorac Cardiovasc Surg 2006;132:769-775
© 2006 The American Association for Thoracic Surgery


General Thoracic Surgery

Radical sublobar resection for small-sized non–small cell lung cancer: A multicenter study

Morihito Okada, MD, PhDa,*, Teruaki Koike, MD, PhDb, Masahiko Higashiyama, MD, PhDc, Yasushi Yamato, MD, PhDb, Ken Kodama, MD, PhDc, Noriaki Tsubota, MD, PhDa

a Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
b Department of Chest Surgery, Niigata Cancer Center Hospital, Niigata City, Niigata, Japan
c Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Osaka, Japan.

Received for publication December 9, 2005; accepted for publication February 6, 2006.

* Address for reprints: Morihito Okada, MD, PhD, Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji-cho13-70, Akashi City 673-8558, Hyogo, Japan. (Email: morihito1217jp{at}aol.com).

Objective: At present, even when early-stage, small-sized non–small cell lung cancers are being increasingly detected, lesser resection has not become the treatment of choice. We sought to compare sublobar resection (segmentectomy or wedge resection) with lobar resection to test which one is the appropriate procedure for such lesions.

Methods: From 1992 to 2001, a nonrandomized study was performed in 3 institutes for patients with a peripheral cT1N0M0 non–small cell lung cancer of 2 cm or less who were able to tolerate a lobectomy. The results of the sublobar resection group enrolled preoperatively (n = 305) were compared with those of the lobar resection group (n = 262).

Results: Except for distribution of tumor location, there were no significant differences in any variable, patient characteristics, curability, pathologic stage, morbidity, or recurrence rate. Median follow-up was more than 5 years. Disease-free and overall survivals were similar in both groups with 5-year survivals of 85.9% and 89.6% for the sublobar resection group and 83.4% and 89.1% for the lobar resection group, respectively. Multivariate analysis confirmed that the recurrence rate and prognosis associated with sublobar resection were not inferior to those obtained with lobar resection. Postoperative lung function was significantly better in patients who underwent sublobar resection.

Conclusions: Sublobar resection should be considered as an alternative for stage IA non–small cell lung cancers 2 cm or less, even in low-risk patients. These results could lay the foundation for starting randomized controlled trials anew, which would bring great changes of lung cancer surgery in this era of early detection of lung cancer.



Abbreviations and Acronyms CT = computed tomography; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; LCSG = Lung Cancer Study Group; NSCLC = non–small cell lung cancer





This article has been cited by other articles:


Home page
Eur Respir JHome page
J-J. Hung, W-J. Jeng, J-S. Liu, and W-H. Hsu
Differential diagnosis and management of focal pulmonary ground-glass opacities
Eur. Respir. J., October 1, 2009; 34(4): 1008 - 1009.
[Full Text] [PDF]


Home page
Eur Respir JHome page
M. Infante
From the authors:
Eur. Respir. J., October 1, 2009; 34(4): 1009 - 1010.
[Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
M. Okada
Invited commentary.
Ann. Thorac. Surg., October 1, 2009; 88(4): 1111 - 1111.
[Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
N. Misaki, S. S. Chang, M. Gotoh, Y. Yamamoto, K. Satoh, and H. Yokomise
A novel method for determining adjacent lung segments with infrared thoracoscopy
J. Thorac. Cardiovasc. Surg., September 1, 2009; 138(3): 613 - 618.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
H. Oizumi, N. Kanauchi, H. Kato, M. Endoh, S.-i. Takeda, J. Suzuki, K. Fukaya, and M. Sadahiro
Total thoracoscopic pulmonary segmentectomy
Eur. J. Cardiothorac. Surg., August 1, 2009; 36(2): 374 - 377.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Moriya, Y. Iwadate, Y. Takiguchi, T. Uno, Y. Nakatani, and I. Yoshino
Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large-cell neuroendocrine carcinoma.
J. Thorac. Cardiovasc. Surg., August 1, 2009; 138(2): 446 - 453.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
A. Kilic, M. J. Schuchert, B. L. Pettiford, A. Pennathur, J. R. Landreneau, J. P. Landreneau, J. D. Luketich, and R. J. Landreneau
Anatomic Segmentectomy for Stage I Non-Small Cell Lung Cancer in the Elderly.
Ann. Thorac. Surg., June 1, 2009; 87(6): 1662 - 1668.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
A. Watanabe, S. Ohori, S. Nakashima, T. Mawatari, N. Inoue, Y. Kurimoto, and T. Higami
Feasibility of video-assisted thoracoscopic surgery segmentectomy for selected peripheral lung carcinomas
Eur. J. Cardiothorac. Surg., May 1, 2009; 35(5): 775 - 780.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
N. Kanauchi, H. Oizumi, T. Honma, H. Kato, M. Endo, J. Suzuki, K. Fukaya, and M. Sadahiro
Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer
Eur. J. Cardiothorac. Surg., April 1, 2009; 35(4): 706 - 711.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
M. Infante, R. F. Lutman, S. Imparato, M. Di Rocco, G. L. Ceresoli, V. Torri, E. Morenghi, F. Minuti, S. Cavuto, E. Bottoni, et al.
Differential diagnosis and management of focal ground-glass opacities
Eur. Respir. J., April 1, 2009; 33(4): 821 - 827.
[Abstract] [Full Text] [PDF]


Home page
ICVTSHome page
T. Chamogeorgakis, C. Ieromonachos, E. Georgiannakis, and D. Mallios
Does lobectomy achieve better survival and recurrence rates than limited pulmonary resection for T1N0M0 non-small cell lung cancer patients?
Interactive CardioVascular and Thoracic Surgery, March 1, 2009; 8(3): 364 - 372.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
R. Rami-Porta and M. Tsuboi
Sublobar resection for lung cancer
Eur. Respir. J., February 1, 2009; 33(2): 426 - 435.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
B. A. Whitson, S. S. Groth, S. J. Duval, S. J. Swanson, and M. A. Maddaus
Surgery for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review of the Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Approaches to Lobectomy
Ann. Thorac. Surg., December 1, 2008; 86(6): 2008 - 2018.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
K. Yamamoto, Y. Miyamoto, A. Ohsumi, F. Kojima, N. Imanishi, K. Matsuoka, M. Ueda, and C. Hamada
Sleeve lung resection for lung cancer: Analysis according to the type of procedure.
J. Thorac. Cardiovasc. Surg., November 1, 2008; 136(5): 1349 - 1356.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
W. Sienel, S. Dango, A. Kirschbaum, B. Cucuruz, W. Horth, C. Stremmel, and B. Passlick
Sublobar resections in stage IA non-small cell lung cancer: segmentectomies result in significantly better cancer-related survival than wedge resections
Eur. J. Cardiothorac. Surg., April 1, 2008; 33(4): 728 - 734.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
H. Nakayama, K. Yamada, H. Saito, F. Oshita, H. Ito, Y. Kameda, and K. Noda
Sublobar Resection for Patients With Peripheral Small Adenocarcinomas of the Lung: Surgical Outcome is Associated With Features on Computed Tomographic Imaging
Ann. Thorac. Surg., November 1, 2007; 84(5): 1675 - 1679.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
M. J. Schuchert, B. L. Pettiford, S. Keeley, T. A. D'Amato, A. Kilic, J. Close, A. Pennathur, R. Santos, H. C. Fernando, J. R. Landreneau, et al.
Anatomic Segmentectomy in the Treatment of Stage I Non-Small Cell Lung Cancer
Ann. Thorac. Surg., September 1, 2007; 84(3): 926 - 933.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
M. Okada, S. Tauchi, K. Iwanaga, T. Mimura, Y. Kitamura, H. Watanabe, S. Adachi, T. Sakuma, and C. Ohbayashi
Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas
J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1448 - 1454.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
M. Okada, T. Mimura, J. Ikegaki, H. Katoh, H. Itoh, and N. Tsubota
A novel video-assisted anatomic segmentectomy technique: Selective segmental inflation via bronchofiberoptic jet followed by cautery cutting
J. Thorac. Cardiovasc. Surg., March 1, 2007; 133(3): 753 - 758.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.