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J Thorac Cardiovasc Surg 2006;132:1030-1036
© 2006 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

Midterm results of endovascular treatment of atherosclerotic aneurysms of the descending thoracic aorta

Bertrand Marcheix, MDa, Camille Dambrin, MD, PhDa, Jean-Philippe Bolduc, MDb, Catherine Arnaud, MDc, Christophe Cron, MDa, Lucy Hollington, MDd, Antoine Mugniot, MDa, Philippe Soula, MDa, Mehdi Bennaceur, MDb, Valérie Chabbert, MDb, Pierre Massabuau, MDe, Philippe Otal, MDb, Alain Cérène, MDa, Hervé Rousseau, MD, PhDb,*

a Department of Thoracic and Cardiovascular Surgery, Rangueil University Hospital, Toulouse, France
b Department of Radiology, Rangueil University Hospital, Toulouse, France
e Department of Cardiology, Rangueil University Hospital, Toulouse, France
c Department of Epidemiology and Biostatistics, Toulouse University Hospital, Toulouse, France
d Department of Cardiology, Montauban General Hospital, Montauban, France.

Received for publication March 4, 2006; revisions received June 24, 2006; accepted for publication July 7, 2006.

* Address for reprints: Hervé Rousseau, MD, Radiology Department, Rangueil University Hospital, TSA 50032, 1 Avenue Jean Poulhès, 31059 Toulouse, Cedex 9, France. (Email: rousseau.h{at}chu-toulouse.fr).

OBJECTIVE: We sought to determine the midterm results of endovascular repair of atherosclerotic aneurysms of the thoracic descending aorta by using second-generation, commercially available stent grafts.

METHODS: Between 1996 and 2005, 45 patients (mean age, 68 ± 11 years) with aneurysms of the descending thoracic aorta underwent endovascular repair. Aortic dissections, penetrating ulcers, and traumatisms were excluded. The mean follow-up was 24.7 ± 21.6 months (maximum, 6.7 years).

RESULTS: No patients died, and no conversion to surgical intervention was required during the procedures. Three (6.7%) patients died during the first month, and 6 (14.7%) died later on. The main complications were strokes (13.3%), vascular access complications (8.9%), aortic complications (6.6%), paraplegia (4.4%), and sudden deaths (4.4%). Nineteen (42%) primary endoleaks were encountered: 3 required reinterventions, 15 spontaneously thrombosed, and 1 patient died. Except for 2 sudden unexplained deaths, no aortic complications were observed after 1 month. Actuarial survival estimates at 1, 3, and 5 years were 87.6% ± 5.3%, 76.9% ± 7.4%, and 70.6% ± 9.2%, respectively. Actuarial freedom from death related to the treated aortic disease was 94.3% ± 4.0%, 94.3% ± 4.0%, and 86.4% ± 8.4% at 1, 3, and 5 years, respectively. Aspirin status of greater than 3 (P = .005), high aortic diameter (P = .007), and long covered lengths (P = .02) were determinant for mortality. Actuarial freedom from complication was 62.6% ± 7.7%, 58.9% ± 8.1%, and 58.9% ± 8.1% at 1, 3, and 5 years, respectively. The location of the aneurysm (P = .05) and a high aortic diameter (P = .04) were both determinants for endoleaks.

CONCLUSIONS: Stent grafting of atherosclerotic aneurysm of the thoracic descending aorta is safe and effective. Further studies are mandatory to determine the most relevant indications and the long-term efficacy of such treatment.




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