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Bahaaldin Alsoufi
Mitesh V. Badiwala
Brian W. McCrindle
John G. Coles
Christopher A. Caldarone
William G. Williams
Glen S. Van Arsdell
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J Thorac Cardiovasc Surg 2006;132:1072-1080
© 2006 The American Association for Thoracic Surgery

Surgery for Congenital Heart Disease

Surgical repair of multiple muscular ventricular septal defects: The role of re-endocardialization strategy

Bahaaldin Alsoufi, MDa,b, Tara Karamlou, MDa, Masaki Osaki, MDa, Mitesh V. Badiwala, MDa, Chan Chee Ching, MSa, Ann Dipchand, MDa, Brian W. McCrindle, MD, MPHa, John G. Coles, MDa, Christopher A. Caldarone, MDa, William G. Williams, MDa, Glen S. Van Arsdell, MDa,*

a Cardiac Center, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
b King Faisal Heart Institute, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Read at the Eighty-sixth Annual Meeting of The American Association for Thoracic Surgery, Philadelphia, Pa, April 29-May 3, 2006.

Received for publication May 12, 2006; revisions received July 11, 2006; accepted for publication July 13, 2006.

* Address for reprints: Glen S. Van Arsdell, MD, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada, M5G 1X8. (Email: glen.vanarsdell{at}sickkids.on.ca).

OBJECTIVE: Surgical repair of multiple muscular ventricular septal defects (Swiss cheese septum) is associated with important morbidity and mortality. We sought to examine factors associated with permanent heart block, early mortality, and time-related survival. Additionally, we evaluated a new approach, transatrial re-endocardialization of interventricular septum, to mitigate risk.

METHODS: One hundred sixteen patients underwent surgery for multiple muscular ventricular septal defects (1982-2005), of whom 64 (55%) had associated cardiac anomalies. Twenty-seven consecutive patients (median age 0.54 years, range 15 days-7.2 years) underwent transatrial re-endocardialization (2002-2005). Forty-four percent had Swiss cheese septum (>4 defects). Multivariable regression analysis determined risk factors for pacemaker and survival.

RESULTS: Operative mortality for the entire cohort was 9%. Risk factors for death were double-outlet right ventricle (odds ratio 44.7, P = .003), ventriculotomy (odds ratio 6.4, P = .03), and fewer multiple muscular ventricular septal defects repaired (odds ratio 4.7/defect, P = .04). Era mortalities differed: 16% for 1982 through 1990, 13% for 1990 through 1998, and 0% for 1999 through 2005, P = .006). Fourteen patients (12%) required a pacemaker. Time-related survivals at 1 and 10 years were 90% ± 3% and 82% ± 5%. Risk factors for death were double-outlet right ventricle (hazard ratio 8.3, P = .02) and longer bypass (hazard ratio 1.02/min, P = .02). In 27 re-endocardialization patients, a combined closure strategy to close 184 defects were applied: transatrial re-endocardialization (median 5, range 2-21), patch (median 1, range 0-4), and device (range 0-1). Post-repair ventricular function was good in 25 of 27 patients. The median number of residual defects was 1.5 (range 0-3), and median residual jet width on color Doppler was 2.3 mm (range 0-4.2 mm). One child required a pacemaker. There were no early or late deaths.

CONCLUSIONS: Outcome of surgical repair of multiple muscular ventricular septal defects (Swiss cheese septum) has improved. Transatrial re-endocardialization strategy enables early complete or nearly complete obliteration of multiple muscular ventricular septal defects with minimal residual lesions (shunt, ventricular dysfunction). Long cardiopulmonary bypass duration is well tolerated. The incidence of permanent heart block has improved. Early echocardiographic and clinical outcomes are promising.

Abbreviations and Acronyms CPB = cardiopulmonary bypass; DORV = double-outlet right ventricle; MVSD = muscular ventricular septal defect; mMVSDs = multiple muscular ventricular septal defects; TAR = transatrial re-endocardialization; VSD = ventricular septal defect




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