JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Hiroshi Date
Motoi Aoe
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sugimoto, S.
Right arrow Articles by Sano, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sugimoto, S.
Right arrow Articles by Sano, Y.

J Thorac Cardiovasc Surg 2006;132:1213-1218
© 2006 The American Association for Thoracic Surgery

Cardiothoracic Transplantation

Bilateral native lung–sparing lobar transplantation in a canine model

Seiichiro Sugimoto, MD, Hiroshi Date, MD*, Ryujiro Sugimoto, MD, Motoi Aoe, MD, Yoshifumi Sano, MD

Department of Cancer and Thoracic Surgery, Okayama University Graduate School, Okayama, Japan.

Received for publication April 23, 2006; revisions received July 6, 2006; accepted for publication July 12, 2006.

* Address for reprints: Hiroshi Date, MD, Department of Cancer and Thoracic Surgery (Surgery II), Okayama University Graduate School, 2-5-1 Shikata Cho, Okayama 700-8558, Japan. (Email: hdate{at}md.okayama-u.ac.jp).

OBJECTIVE: Bilateral living-donor lobar lung transplantation has become an accepted approach in response to the cadaveric lung donor shortage. Because only one lobe is implanted in each chest cavity, this procedure is usually confined to patients of small size. The purpose of this study was to develop a technique of bilateral native lung–sparing lobar transplantation that can be applied to large adult patients.

METHODS: Bilateral native lung–sparing lobar transplantation was performed in 12 pairs of dogs. In donor animals the right middle, lower, and cardiac lobes were separated as a right graft, and the left lower lobe was separated as a left graft. In recipient animals these 2 grafts were implanted in the natural anatomic position with sparing native right upper, left upper, and middle lobes. In an acute study (n = 6), transplanted graft function was assessed for 3 hours after ligation of the pulmonary artery branches to the native spared lobes. In a chronic study (n = 6) the immunosuppressed recipients were observed for 3 weeks to assess the quality of bronchial healing and long-term pulmonary function.

RESULTS: Morphologic adaptation of the 2 grafts was found to be excellent. All 6 animals in the acute study showed excellent pulmonary function. Five of 6 animals in the chronic study survived for 3 weeks, with excellent pulmonary function and satisfactory bronchial healing.

CONCLUSION: Bilateral native lung–sparing lobar transplantation was technically possible and associated with excellent pulmonary function and good bronchial healing in a canine experimental model.

Abbreviations and Acronyms BNSLT = bilateral native lung–sparing lobar transplantation; LDLLT = living-donor lobar lung transplantation; UDLLT = unilateral double lobar lung transplantation






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.