JTCS Medtronic Endurant
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Christof Stamm
Yeong-Hoon Choi
Andreas Liebold
Gustav Steinhoff
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stamm, C.
Right arrow Articles by Steinhoff, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stamm, C.
Right arrow Articles by Steinhoff, G.
Related Collections
Right arrow Coronary disease
Right arrow Myocardial infarction
Right arrowRelated Article

J Thorac Cardiovasc Surg 2007;133:717-725
© 2007 The American Association for Thoracic Surgery

Evolving Technology

Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: Safety and efficacy studies

Christof Stamm, MDa, Hans-Dieter Kleine, MDb, Yeong-Hoon Choi, MDa, Simone Dunkelmann, MDc, Jan-Arne Lauffsa, Björn Lorenzen, MDd, Arpad David, MDa, Andreas Liebold, MDa, Christoph Nienaber, MDe, David Zurakowski, PhDf, Mathias Freund, MDb, Gustav Steinhoff, MDa,*

a Department of Cardiac Surgery, University of Rostock, Rostock, Germany
b Department of Hematology, University of Rostock, Rostock, Germany
c Department of Nuclear Medicine, University of Rostock, Rostock, Germany
d Department of Radiology, University of Rostock, Rostock, Germany
e Department of Cardiology, University of Rostock, Rostock, Germany
f Departments of Orthopedic Surgery and Biostatistics, Children’s Hospital Boston, Harvard Medical School, Boston, Mass.

Received for publication May 1, 2006; revisions received July 30, 2006; accepted for publication August 3, 2006.

* Address for reprints: Gustav Steinhoff, MD, Klinik für Herzchirurgie, Universität Rostock, Schillingallee 35, 18057 Rostock, Germany (Email: gustav.steinhoff{at}med.uni-rostock.de).

Objectives: Cell therapy may offer novel therapeutic options for chronic ischemic heart disease. In a clinical trial, we first assessed the feasibility and safety of intramyocardial CD133+ bone marrow cell injection together with coronary artery bypass grafting (CABG). We then tested the hypothesis that CABG plus CD133+ cell injection would result in better contractile function than CABG alone.

Methods: Fifteen patients took part in the safety study, followed by 40 patients who underwent either CABG with cell therapy or CABG alone. Bone marrow was harvested from the iliac crest one day before surgery, and purified CD133+ progenitor cells were injected in the infarct border zone during the CABG operation. LV function was measured by echocardiography and myocardial perfusion by SPECT.

Results: In the safety study, no procedure-related complications were observed for up to 3 years. LV injection fraction (LVEF) increased from 39.0% ± 8.7% preoperatively to 50.2% ± 8.5% at 6 months and 47.9% ± 6.0% at 18 months (F = 6.03, P = .012). In the efficacy study, LCEF rose form 37.4% ± 8.4% to 47.1% ± 8.3% at 6 months in the group with CABG and cell therapy (F = 24.16, P < .0001) but only from 37.9% ± 10.3% to 41.3% ± 9.1% in the CABG-only group (F = 7.72, P = .012). LVEF was significantly higher at 6 months in the group with CABG and cell therapy than in the CABG-only group (P = .03). Similarly, perfusion of the infarcted myocardium improved more in patients treated with CABG and cell therapy than in those treated with CABG alone.

Conclusion: Intramyocardial delivery of purified bone marrow stem cells together with CABG surgery is safe and provides beneficial effects, though it remains to be seen whether thewe effects produce a lasting clinical advantage.

Abbreviations and Acronyms CABG = coronary artery bypass grafting; ECG = electrocardiography; LV = left ventricle; LVEF = LV ejection fraction; MRI = magnetic resonance imaging; PBS = phosphate-buffered saline solution


Related Article

Bone marrow cell therapy for heart disease: A few good men and women wanted
Shafie Fazel
J. Thorac. Cardiovasc. Surg. 2007 133: 599-600. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. Yerebakan, A. Kaminski, B. Westphal, P. Donndorf, A. Glass, A. Liebold, C. Stamm, and G. Steinhoff
Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133+ bone marrow stem cell transplant
J. Thorac. Cardiovasc. Surg., December 1, 2011; 142(6): 1530 - 1539.e3.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Takehara and H. Matsubara
Cardiac regeneration therapy: connections to cardiac physiology
Am J Physiol Heart Circ Physiol, December 1, 2011; 301(6): H2169 - H2180.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. H. Wu, X. M. Mo, Z. C. Han, and B. Zhou
Stem Cell Engraftment and Survival in the Ischemic Heart
Ann. Thorac. Surg., November 1, 2011; 92(5): 1917 - 1925.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. Donndorf, G. Kundt, A. Kaminski, C. Yerebakan, A. Liebold, G. Steinhoff, and A. Glass
Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: A meta-analysis
J. Thorac. Cardiovasc. Surg., October 1, 2011; 142(4): 911 - 920.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B.-E. Strauer and G. Steinhoff
10 Years of Intracoronary and Intramyocardial Bone Marrow Stem Cell Therapy of the Heart: From the Methodological Origin to Clinical Practice
J. Am. Coll. Cardiol., September 6, 2011; 58(11): 1095 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
N. Bonaros, H. Sondermeijer, D. Wiedemann, B. Schlechta, T. Schachner, M. Schuster, T. Seki, T. P. Martens, S. Itescu, and A. A. Kocher
Downregulation of the CXC chemokine receptor 4/stromal cell-derived factor 1 pathway enhances myocardial neovascularization, cardiomyocyte survival, and functional recovery after myocardial infarction
J. Thorac. Cardiovasc. Surg., September 1, 2011; 142(3): 687 - 696.e2.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
A. M. Mozid, S. Arnous, E. C. Sammut, and A. Mathur
Stem cell therapy for heart diseases
Br. Med. Bull., June 1, 2011; 98(1): 143 - 159.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
K. Malliaras and E. Marban
Cardiac cell therapy: where we've been, where we are, and where we should be headed
Br. Med. Bull., June 1, 2011; 98(1): 161 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. W. Bergmann
WNT Signaling in Adult Cardiac Hypertrophy and Remodeling: Lessons Learned From Cardiac Development
Circ. Res., November 12, 2010; 107(10): 1198 - 1208.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
A. Rivas-Plata, J. Castillo, M. Pariona, and A. Chunga
Bypass Grafts and Cell Transplant in Heart Failure with Low Ejection Fraction
Asian Cardiovasc Thorac Ann, October 1, 2010; 18(5): 425 - 429.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Kim, H.-J. Cho, S.-W. Kim, B. Liu, Y. J. Choi, J. Lee, Y.-D. Sohn, M.-Y. Lee, M. A. Houge, and Y.-s. Yoon
CD31+ Cells Represent Highly Angiogenic and Vasculogenic Cells in Bone Marrow: Novel Role of Nonendothelial CD31+ Cells in Neovascularization and Their Therapeutic Effects on Ischemic Vascular Disease
Circ. Res., September 3, 2010; 107(5): 602 - 614.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y. Zhang, S. Wong, J. Lafleche, S. Crowe, T. G. Mesana, E. J. Suuronen, and M. Ruel
In vitro functional comparison of therapeutically relevant human vasculogenic progenitor cells used for cardiac cell therapy
J. Thorac. Cardiovasc. Surg., July 1, 2010; 140(1): 216 - 224.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Herrmann, A. M. Abarbanell, B. R. Weil, Y. Wang, J. A. Poynter, M. C. Manukyan, and D. R. Meldrum
Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-{alpha} improves acute myocardial function
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2010; 299(1): R371 - R378.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. Guo, R. K. Li, and R. D. Weisel
Back to the bench: The rejuvenation of stem cell therapy--the therapeutic potential of CD133+ progenitor cells
J. Thorac. Cardiovasc. Surg., June 1, 2010; 139(6): 1369 - 1370.
[Full Text] [PDF]

Home page
 Br Med BullHome page
J. Lee and C. M. Terracciano
Cell therapy for cardiac repair
Br. Med. Bull., June 1, 2010; 94(1): 65 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Cardiovasc DisHome page
C. Nesselmann, W. Li, N. Ma, and G. Steinhoff
Stem cell-mediated neovascularization in heart repair
Therapeutic Advances in Cardiovascular Disease, February 1, 2010; 4(1): 27 - 42.
[Abstract] [PDF]

Home page
 MMCTSHome page
H. M. Klein, A. Assmann, A. Lichtenberg, and M. Heke
Intraoperative CD133+ cell transplantation during coronary artery bypass grafting in ischemic cardiomyopathy
MMCTS, January 1, 2010; 2010(0809): mmcts.2009.003947 - mmcts.2009.003947.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. L. Herrmann, A. M. Abarbanell, B. R. Weil, Y. Wang, M. Wang, J. Tan, and D. R. Meldrum
Cell-Based Therapy for Ischemic Heart Disease: A Clinical Update
Ann. Thorac. Surg., November 1, 2009; 88(5): 1714 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
V. K. Lai, K.-L. Ang, W. Rathbone, N. J. Harvey, and M. Galinanes
Randomized controlled trial on the cardioprotective effect of bone marrow cells in patients undergoing coronary bypass graft surgery
Eur. Heart J., October 1, 2009; 30(19): 2354 - 2359.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
S. J. Brunskill, C. J. Hyde, C. J. Doree, S. M. Watt, and E. Martin-Rendon
Route of delivery and baseline left ventricular ejection fraction, key factors of bone-marrow-derived cell therapy for ischaemic heart disease
Eur J Heart Fail, September 1, 2009; 11(9): 887 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll Cardiol IntvHome page
P. G. Kyrtatos, P. Lehtolainen, M. Junemann-Ramirez, A. Garcia-Prieto, A. N. Price, J. F. Martin, D. G. Gadian, Q. A. Pankhurst, and M. F. Lythgoe
Magnetic Tagging Increases Delivery of Circulating Progenitors in Vascular Injury
J. Am. Coll. Cardiol. Intv., August 1, 2009; 2(8): 794 - 802.
[Abstract] [Full Text] [PDF]

Home page
 DMMHome page
K. D. Boudoulas and A. K. Hatzopoulos
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease
Dis. Model. Mech., July 1, 2009; 2(7-8): 344 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Cardiovasc DisHome page
C. Stamm, Y.-H. Choi, B. Nasseri, and R. Hetzer
A heart full of stem cells: the spectrum of myocardial progenitor cells in the postnatal heart
Therapeutic Advances in Cardiovascular Disease, June 1, 2009; 3(3): 215 - 229.
[Abstract] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S.-H. Li, T. Y.Y. Lai, Z. Sun, M. Han, E. Moriyama, B. Wilson, S. Fazel, R. D. Weisel, T. Yau, J. C. Wu, et al.
Tracking cardiac engraftment and distribution of implanted bone marrow cells: Comparing intra-aortic, intravenous, and intramyocardial delivery.
J. Thorac. Cardiovasc. Surg., May 1, 2009; 137(5): 1225 - 33.e1.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Q. Zhao, Y. Sun, L. Xia, A. Chen, and Z. Wang
Randomized Study of Mononuclear Bone Marrow Cell Transplantation in Patients With Coronary Surgery
Ann. Thorac. Surg., December 1, 2008; 86(6): 1833 - 1840.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. C. Chachques, J. C. Trainini, N. Lago, M. Cortes-Morichetti, O. Schussler, and A. Carpentier
Myocardial Assistance by Grafting a New Bioartificial Upgraded Myocardium (MAGNUM Trial): Clinical Feasibility Study
Ann. Thorac. Surg., March 1, 2008; 85(3): 901 - 908.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. K. Burt, Y. Loh, W. Pearce, N. Beohar, W. G. Barr, R. Craig, Y. Wen, J. A. Rapp, and J. Kessler
Clinical Applications of Blood-Derived and Marrow-Derived Stem Cells for Nonmalignant Diseases
JAMA, February 27, 2008; 299(8): 925 - 936.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Zhang, P. Song, Y. Tang, X.-l. Zhang, S.-h. Zhao, Y.-j. Wei, and S.-s. Hu
Injection of bone marrow mesenchymal stem cells in the borderline area of infarcted myocardium: heart status and cell distribution.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1234 - 1240.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The American Association for Thoracic Surgery.