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J Thorac Cardiovasc Surg 2007;134:284-289
© 2007 The American Association for Thoracic Surgery

Surgery for Congenital Heart Disease

Pediatric cardiac surgery without homologous blood transfusion, using a miniaturized bypass system in infants with lower body weight

Kagami Miyaji, MDa,*, Satoshi Kohira, CCCPa, Takashi Miyamoto, MDa, Kouki Nakashima, MDa, Hajime Sato, MD, PhDb, Kuniyoshi Ohara, MDa, Hirokuni Yoshimura, MDa

a Department of Thoracic and Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan
b Department of Public Health, University of Tokyo, School of Medicine, Tokyo, Japan.

Received for publication November 27, 2006; revisions received February 13, 2007; accepted for publication February 27, 2007.

* Address for reprints: Kagami Miyaji, MD, Department of Thoracic and Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan, Kitasato 1-15-1, Sagamihara 228-8555, Japan. (Email: kagami111{at}aol.com).

Objective: We have established a low–priming volume cardiopulmonary bypass system for pediatric heart surgery to avoid homologous blood transfusion. The priming volume of our system is down to 140 mL for patients weighing less than 7 kg. We can prime the bypass circuits without blood products for patients weighing more than 4 kg.

Methods: Seventy consecutive patients weighing 4 to 7 kg underwent heart surgery with a bloodless prime from October 2003 to September 2006. The type of procedures (Risk Adjustment in Congenital Heart Surgery category) included the following: category 1: atrial septal defect (n = 3); category 2: ventricular septal defect, tetralogy of Fallot, bidirectional Glenn shunt, and others (n = 55); category 3: atrioventricular septal defect, double-outlet right ventricle, and others (n = 8); category 4: Rastelli procedure for transposition of the great arteries (n = 3); and category 6, Damus–Kaye–Stansel procedure (n = 1). Transfusion criteria were hematocrit less than 20%, mixed venous oxygen saturation less than 70%, regional cerebral oxygenation less than 50%, and plasma lactate level greater than 4.0 mmol/L during bypass.

Results: The mean age and body weight were 7.3 ± 5.4 months and 5.4 ± 0.8 kg, respectively. Forty-five patients (64%) underwent transfusion-free procedures. Preoperative hematocrit, age, body weight, complexity of procedure and cardiopulmonary bypass time were compared between patients with and without transfusion. Bypass time and Risk Adjustment in Congenital Heart Surgery risk category in patients with transfusion were significantly greater than those in patients without (P < .0001, and P < .05, respectively). Body weight in patients without transfusion was significantly greater than that in patients with (P < .01). In multiple regression analysis, the determinants of blood transfusion were the bypass time and body weight (odds ratio 1.026, 95% confidence interval 1.011–.040, P < .0001, and odds ratio 0.366, 95% confidence interval 0.171–0.785, P < .01).

Conclusions: It is possible to do complex transfusion-free procedures safely for patients weighing more than 4 kg by using the low–priming volume circuit. The limiting factors of bloodless heart surgery are not preoperative hematocrit and complexity of procedure but the cardiopulmonary bypass time and the patient’s body weight.

Abbreviations and Acronyms CPB = cardiopulmonary bypass; MUF = modified ultrafiltration; RACHS = Risk Adjustment in Congenital Heart Surgery; rSO 2 = regional cerebral oxygenation; SvO 2 = mixed venous oxygen saturation




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K. Miyaji, T. Miyamoto, S. Kohira, K. Nakashima, N. Inoue, H. Sato, and K. Ohara
Miniaturized cardiopulmonary bypass system in neonates and small infants
Interactive CardioVascular and Thoracic Surgery, February 1, 2008; 7(1): 75 - 79.
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