JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by An, Y.
Right arrow Articles by Xiao, Y.-B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by An, Y.
Right arrow Articles by Xiao, Y.-B.
Related Collections
Right arrow Extracorporeal circulation

J Thorac Cardiovasc Surg 2007;134:342-350
© 2007 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology

Growth hormone prevents acute liver injury induced by cardiopulmonary bypass in a rat model

Yong An, MD, Ying-Bin Xiao, MD*

Department of Cardiovascular Surgery, Xin-Qiao Hospital, Third Military Medical University, Chongqing, China.

Received for publication November 13, 2006; revisions received February 7, 2007; accepted for publication February 14, 2007.

* Address for reprints: Ying-Bin Xiao, MD, Department of Cardiovascular Surgery, Xin-Qiao Hospital, Third Military Medical University, ShaPingBa District, Chongqing 400037, China. (Email: anyongsmcvs{at}163.com).

Objective: Cardiopulmonary bypass–induced acute liver injury is a life-threatening complication thought to be associated with the inflammatory response and the acute-phase response. Recombinant human growth hormone can modulate the acute-phase response and inflammatory response. We tested the protective effect of growth hormone on cardiopulmonary bypass–induced liver injury in the rat.

Methods: Adult male Sprague–Dawley rats (group G received 2.5 mg/kg recombinant human growth hormone intramuscularly at 8 AM every 24 hours for 3 days and just before the initiation of cardiopulmonary bypass; group C served as a control group) underwent cardiopulmonary bypass (120 minutes, 120 mL · kg–1 · min–1, 34°C) and were killed 3 hours after the termination of cardiopulmonary bypass.

Results: Administration of recombinant human growth hormone markedly increased serum insulin-like growth factor and insulin-like growth factor–binding protein 3 levels compared with those seen in group C. Group G showed significantly lower serum concentrations of alanine aminotransferase and total bilirubin after cardiopulmonary bypass termination. Those receiving recombinant human growth hormone demonstrated a significant increase in serum prealbumin and transferrin levels and a marked decrease in serum amyloid A and C-reactive protein levels. Recombinant human growth hormone significantly decreased serum tumor necrosis factor {alpha} and interleukin 1ß levels, whereas no changes were found for serum interleukin 6 and interleukin 10 levels. Recombinant human growth hormone significantly increased total liver protein content and hepatocyte proliferation and decreased hepatocyte apoptosis versus values seen in group C.

Conclusions: These results suggest that growth hormone prevents cardiopulmonary bypass–induced acute liver injury in a rat model through decreases in acute-phase proteins, proinflammatory cytokines tumor necrosis factor {alpha} and interleukin 1ß, and hepatocyte apoptosis, which is associated with increases in constitutive hepatic proteins, total liver protein content, and hepatocyte proliferation. This strategy of pretreatment with growth hormone might be a prospective management for preventing acute liver injury when major cardiac surgery with cardiopulmonary bypass is performed.

Abbreviations and Acronyms APP = acute-phase protein; APR = acute-phase response; CPB = cardiopulmonary bypass; GH = growth hormone; GHBP = growth hormone–binding protein; IGF = insulin-like growth factor; JAK = Janus kinase; NF = nuclear factor; SAA = serum amyloid A; STAT = signal transducer and activator of transcription; TNF = tumor necrosis factor






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The American Association for Thoracic Surgery.