HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Mehmet Muharrem Erol Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tekinbas, C. Articles by Topbas, M. Search for Related Content PubMed PubMed Citation Articles by Tekinbas, C. Articles by Topbas, M. Related Collections Trachea and bronchi

J Thorac Cardiovasc Surg 2007;134:405-410
© 2007 The American Association for Thoracic Surgery

General Thoracic Surgery

One-lung ventilation: For how long?

^a Department of Thoracic Surgery, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
^b Departments of Anesthesiology and Critical Care, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
^c Departments of Histology and Embryology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
^d Department of Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
^e Department of Public Health, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.

Received for publication January 30, 2007; revisions received March 22, 2007; accepted for publication April 12, 2007.

^_* Address for reprints: Celal Tekinbas, MD, Department of Thoracic Surgery, Karadeniz Teknik Üniversitesi, Tp Fakültesi, Göüs Cerrahisi AD, 61080, Trabzon, Turkey. (Email: celaltekinbas3{at}hotmail.com).

Objective: Lung injury induced by one-lung ventilation is rare, but it is a condition that may result in high mortality. This study evaluates the effects of one-lung ventilation and occlusion time on collapsed and contralateral lungs.

Methods: Sprague–Dawley rats were allocated randomly into 7 groups consisting of 6 animals each: sham; O1, 1 hour of occlusion/2 hours of re-expansion; C1, 3 hours of mechanical ventilation control; O2, 2 hours of occlusion/2 hours of re-expansion; C2, 4 hours of mechanical ventilation control; O3, 3 hours of occlusion/2 hours of re-expansion; and C3, 5 hours of mechanical ventilation control groups. In the occlusion groups, the left lung was collapsed by bronchial occlusion. Malondialdehyde activity was determined in the blood, and myeloperoxidase and malondialdehyde activity was determined in the collapsed and contralateral lungs. Lung tissues were also examined histopathologically.

Results: Malondialdehyde and myeloperoxidase levels rose as occlusion duration increased. This increase was greater in the occlusion groups than that in their own control groups. Increases were significant in the O2 compared with the O1 groups (P < .005). Histologically, tissue damage increased as occlusion time rose injury in collapsed and contralateral lungs. Injury was greater in the occlusion groups than injury in their own control groups (P < .005).

Conclusions: Our findings show that biochemical and histopathologic injury occur in collapsed and contralateral lungs in one-lung ventilation, and this injury increases as occlusion time rises. We believe that occlusion and occlusion time–related injury should be borne in mind in the clinic under conditions requiring the application of one-lung ventilation.

This article has been cited by other articles:

				F. T. Lytle and D. R. Brown Appropriate Ventilatory Settings for Thoracic Surgery: Intraoperative and Postoperative Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2008; 12(2): 97 - 108. [Abstract] [PDF]