HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ujjwal K. Chowdhury Srikrishna M. Reddy Panangipalli Venugopal Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chowdhury, U. K. Articles by Venugopal, P. Search for Related Content PubMed Articles by Chowdhury, U. K. Articles by Venugopal, P. Related Collections Congenital - cyanotic Great vessels

J Thorac Cardiovasc Surg 2008;135:69-77
© 2008 The American Association for Thoracic Surgery

Surgery for Congenital Heart Disease

Histopathologic changes in ascending aorta and risk factors related to histopathologic conditions and aortic dilatation in patients with tetralogy of Fallot

^a Department of Cardiothoracic Surgery, All India Institute of Medical Sciences, New Delhi, India
^b Department of Cardiac Pathology, All India Institute of Medical Sciences, New Delhi, India
^c Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Received for publication February 6, 2007; revisions received May 19, 2007; accepted for publication June 1, 2007.

^_* Address for reprints: Dr. Ujjwal K. Chowdhury, Additional Professor, Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi–110029, India. (Email: ujjwalchow{at}rediffmail.com; ujjwalchowdhury{at}gmail.com).

Objective: The purposes of this study were to evaluate the histologic characteristics of the aortic wall and the risk factors related to histopathology and aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot.

Methods: Operatively excised full-thickness aortic wall tissue from 98 consecutive patients undergoing intracardiac repair of tetralogy of Fallot aged 6 months to 47 years (mean 104.5 ± 102.8 months; median 72 months) were studied by light microscopy. The receiver operating characteristic curve analysis was done to quantify the diagnostic accuracy of loss of lamellar counts and multiple logistic regression models.

Results: Twenty-five (25.5%) aortic tissue specimens were indicated as histologically normal and were used as normal controls. The incidence of elastic fragmentation, increased ground substance, medionecrosis, smooth muscle disarray, and fibrosis was 74.5%, 54%, 39.8%, 26.5%, and 57.1%, respectively. A lamellar count of less than 60 was associated with a sensitivity of 80% and a specificity of 87.67%. Area under the receiver operating characteristic curve indicated that 93.37% (standard error ± 0.039) of the time the value of lamellar count was lower for the abnormal histopathology group than for the normal group (P < .001). The risk of aortic dilatation was 15.97 times higher in patients with histopathologically abnormal aorta.

Conclusions: The majority of aortic media of the ascending aorta in cyanotic tetralogy of Fallot indicates significant loss of lamellar units and pre-existing intrinsic aortopathy. The changes are present since infancy and are more pronounced in older patients subjected to long-standing cyanosis and volume overload and may account for or may coexist with the higher incidence of aortic dilatation encountered in these patients.

This article has been cited by other articles:

				U. K. Chowdhury, A. K. Mishra, P. Balakrishnan, S. Sharma, M. Kabra, R. Ray, M. Kalaivani, R. Gupta, R. M. Govindappa, and G. K. Subramaniam Role of fibrillin-1 genetic mutations and polymorphism in aortic dilatation in patients undergoing intracardiac repair of tetralogy of Fallot J. Thorac. Cardiovasc. Surg., September 1, 2008; 136(3): 757 - 766. [Abstract] [Full Text] [PDF]