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J Thorac Cardiovasc Surg 2008;136:650-656
© 2008 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

Chylopericardium in adults: A literature review over the past decade (1996–2006)

Mayo Clinic College of Medicine, Division of Cardiovascular Diseases and Cardiovascular Surgery, Scottsdale, Ariz

Received for publication August 28, 2007; revisions received February 18, 2008; accepted for publication March 30, 2008.

^_* Address for references: Farouk Mookadam, MD, FRCPC, FACC, MSc, 13400 E Shea Blvd, Scottsdale, AZ 85259. (Email: mookadam.farouk{at}mayo.edu).

Objectives: We present a systematic overview of the literature on reported cases of chylous pericardial effusion in adults over the past 10 years, assessing clinical presentation, etiology, diagnosis, and treatment.

Methods: We conducted an evidence-based literature review searching for all reported adult cases of chylopericardium in the past 10 years (January 1996–December 2006).

Results: A total of 33 reported cases of chylopericardium were identified through a systematic literature search. There was no gender bias in the incidence of chylous pericardial effusion. Age at diagnosis varied from 18 to 68 years with a mean ± standard deviation of 36.78 ± 14.71 years. Time from symptom onset to diagnosis was variable (ranging from acute presentation to several years).The most common reported etiology was idiopathic. The diagnosis was made by pericardiocentesis in all patients. A search for secondary causes included computed tomography of the chest, lymphoscintigraphy, and lymphangiography along with radioactive oral ¹³¹I-triolein. Conservative therapy was prescribed in 28 patients and failed in 16, in whom subsequent surgery was necessary. Overall, 21 patients underwent various types of surgery. Thoracic duct ligation with creation of a pericardial window was the most common surgical procedure.

Conclusion: Chylopericardium is a rare entity. The fluid appearance, triglyceride content, cytologic characteristics, and negative cultures are crucial to make the correct diagnosis. Treatment is dependent on the etiology. Surgical management is the most successful. Conservative therapy is reserved for patients with idiopathic chylopericardium, those with an untreatable etiology, those considered at high risk for surgical treatment, or those with a predictably short lifespan.

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