JTCS Click here to go to SJM website.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, H.
Right arrow Articles by Zhou, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Li, H.
Right arrow Articles by Zhou, G.
Related Collections
Right arrow Esophagus - cancer

J Thorac Cardiovasc Surg 2009;137:55-59
© 2009 The American Association for Thoracic Surgery

General Thoracic Surgery

Factors predictive of prognosis after esophagectomy for squamous cell cancer

Houhuai Li, MD, PhDa,*, Qingzhen Zhanga, Lin Xu, MDa, Yijiang Chenb, Yongxiang Weic, Guoren Zhou, MSd

a Division of Thoracic Surgery, Department of Surgery, Jiangsu Province Tumor Hospital, Nanjing, China
b Division of Thoracic Surgery, Department of Surgery, Jiangsu Province People's Hospital, Nanjing, China
c Division of Thoracic Surgery, Department of Surgery, Nanjing Jiangbei People's Hospital, Nanjing, China
d Division of Chemoradiotherapy, Department of Medicine, Jiangsu Province Tumor Hospital, Nanjing, China

Received for publication January 4, 2008; revisions received April 15, 2008; accepted for publication May 10, 2008.

* Address for reprints: Houhuai Li, MD, PhD, Division of Thoracic Surgery, Department of Surgery, Jiangsu Province Tumor Hospital, Beiziting 42#, Nanjing, China. (Email: lihouhuai{at}vip.163.com).

Objective: To evaluate the prognosis after esophagectomy for squamous cell carcinoma of the thoracic esophagus and its prognostic factors.

Methods: Six hundred five patients with primary squamous cell carcinoma of the thoracic esophagus who underwent curative esophagectomy between June 1997 and June 1998 were collected from 3 medical centers. Among them, 26 patients died from the operation and 26 patients did not complete adjuvant treatment owing to toxicity. Univariate and multivariate analysis was performed to identify prognostic factors for survival. The effect of adjuvant treatment on survival was also evaluated.

Results: The 1-, 3-, 5-, and 10-year overall survivals of 605 patients were 90%, 65%, 36%, and 8%, respectively. Multivariate analysis identified the following as independent prognostic factors: number of lymph node metastases (P < .001), histologic differentiation (P < .001), tumor location (P = .002), depth of invasion (P = .020), and vascular invasion (P = .023).

Conclusions: Several pathologic characteristics of the primary tumor are correlated with the outcome of esophagectomy for squamous carcinoma of the thoracic esophagus. Patients with fewer than 2 metastatic nodes after curative esophagectomy have a better prognosis than those with multiple involved nodes (>2). To stratify patients appropriately for prognosis, it is necessary to refine the current 6th edition TNM staging system.

Abbreviations and Acronyms pM = presence of metastasis; pN = lymph node metastases; pT = depth of tumor invasion; SCC = squamous cell carcinoma; UICC = International Union Against Cancer






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2009 by The American Association for Thoracic Surgery.