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J Thorac Cardiovasc Surg 2009;137:82-90
© 2009 The American Association for Thoracic Surgery

Acquired Cardiovascular Disease

Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: Changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database

James M. Brown, MDa,*, Sean M. O'Brien, PhDb, Changfu Wu, PhDa, Jo Ann H. Sikora, CRNPa, Bartley P. Griffith, MDa, James S. Gammie, MDa

a Division of Cardiothoracic Surgery, Department of Surgery, University of Maryland Medical Center Baltimore, Md
b The Duke Clinical Research Institute, Durham, NC

Received for publication July 2, 2008; accepted for publication August 7, 2008.

* Address for reprints: James M. Brown, MD, 22 S Green St, Baltimore, MD 21201. (Email: jbrown{at}smail.umaryland.edu).

Objective: More than 200,000 aortic valve replacements are performed annually worldwide. We describe changes in the aortic valve replacement population during 10 years in a large registry and analyze outcomes.

Methods: The Society of Thoracic Surgeons National Database was queried for all isolated aortic valve replacements between January 1, 1997, and December 31, 2006. After exclusion for endocarditis and missing age or sex data, 108,687 isolated aortic valve replacements were analyzed. Time-related trends were assessed by comparing distributions of risk factors, valve types, and outcomes in 1997 versus 2006. Differences in case mix were summarized by comparing average predicted mortality risks with a logistic regression model. Differences across subgroups and time were assessed.

Results: There was a dramatic shift toward use of bioprosthetic valves. Aortic valve replacement recipients in 2006 were older (mean age 65.9 vs 67.9 years, P < .001) with higher predicted operative mortality risk (2.75 vs 3.25, P < .001); however, observed mortality and permanent stroke rate fell (by 24% and 27%, respectively). Female sex, age older than 70 years, and ejection fraction less than 30% were all related to higher mortality, higher stroke rate and longer postoperative stay. There was a 39% reduction in mortality with preoperative renal failure.

Conclusions: Morbidity and mortality of isolated aortic valve replacement have fallen, despite gradual increases in patient age and overall risk profile. There has been a shift toward bioprostheses. Women, patients older than 70 years, and patients with ejection fraction less than 30% have worse outcomes for mortality, stroke, and postoperative stay.

Abbreviations and Acronyms AVR = aortic valve replacement; STS = Society of Thoracic Surgeons




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