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J Thorac Cardiovasc Surg 2009;137:347-354
© 2009 The American Association for Thoracic Surgery

Congenital Heart Disease

Improvement in long-term survival after hospital discharge but not in freedom from reoperation after the change from atrial to arterial switch for transposition of the great arteries

Jürgen Hörer, MDa,*, Christian Schreiber, MD, PhDa, Julie Cleuziou, MDa, Manfred Vogt, MD, PhDb, Zsolt Prodan, MDa, Raymonde Busch, MScc, Klaus Holper, MD, PhDa, Rüdiger Lange, MD, PhDa

a Department of Cardiovascular Surgery, German Heart Center Munich, Technical University Munich, Munich, Germany
b Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich, Technical University Munich, Munich, Germany
c Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany

Received for publication April 24, 2008; revisions received July 22, 2008; accepted for publication September 12, 2008.

* Address for reprints: Jürgen Hörer, MD, Lazarettstrasse 36, D-80636 Munich, Germany. (Email: hoerer{at}dhm.mhn.de).

Objective: To compare survival, freedom from reoperation, and functional status between atrial switch and arterial switch operations for transposition of the great arteries.

Methods: Data from 88, 329, and 512 patients who underwent Mustard, Senning, and arterial switch operations between 1974 and 2006 were analyzed.

Results: In-hospital mortalities were 8.0% for Mustard, 4.6% for Senning, and 6.4% for arterial switch. Presence of ventricular septal defect (hazard ratio 3.3, P < .001) was the only risk factor for in-hospital mortality in multivariate analysis. Follow-up for Mustard was 22.6 ± 8.1 years, for Senning was 18.2 ± 5.7 years, and for arterial switch was 9.5 ± 5.7 years. Highest survival at 20 years was after arterial switch (96.6% ± 1.3%), followed by Senning (92.6% ± 1.5%) and Mustard (82.4% ± 4.3%). Transposition with ventricular septal defect (hazard ratio 3.1, P < .001), transposition with ventricular septal defect and left ventricular outflow tract obstruction (hazard ratio 3.0, P = .029), and Mustard operation (hazard ratio 2.1, P = .011) emerged as risk factors for late death, with arterial switch a protective factor (hazard ratio 0.3, P = .010). Highest freedom from reoperation at 20 years was after Senning (88.7% ± 1.9%), followed by arterial switch (75.0% ± 6.4%) and Mustard (70.6% ± 5.4%). Presence of complex transposition (hazard ratio 2.1, P < .001), previous palliative operation (hazard ratio 1.8, P = .016), surgery between 1985 and 1995 (hazard ratio 2.6, P = .002), surgery after 1995 (hazard ratio 3.5, P < .001), and Mustard operation (hazard ratio 3.3, P < .001) emerged as risk factors for reoperation.

Conclusion: Change from atrial to arterial switch led to improved long-term survival after hospital discharge but not to lower incidence of reoperation. Survival and freedom from reoperation are determined by morphology.

Abbreviations and Acronyms IVS = intact ventricular septum; LVOTO = left ventricular outflow tract obstruction; NYHA = New York Heart Association; TGA = transposition of the great arteries; VSD = ventricular septal defect




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