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Zhi-yun Xu
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J Thorac Cardiovasc Surg 2009;137:1475-1480
© 2009 The American Association for Thoracic Surgery

Acquired Cardiovascular Disease

Surgical treatment of multivalvular endocarditis: Twenty-one–year single center experience

Feng Yao, MD, Lin Han, MD, Zhi-yun Xu, MD*, Liang-jian Zou, MD, Sheng-dong Huang, MD, Zhi-nong Wang, MD, Fang-lin Lu, MD, Ying-long Yao, MD

Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China

Received for publication August 1, 2008; revisions received October 20, 2008; accepted for publication November 26, 2008.

* Address for reprints: Zhi-yun Xu, MD, Department of Cardiothoracic Surgery, Changhai Hospital, 174 Changhai Road, Shanghai 200433, People's Republic of China. (Email: zhiyunx{at}hotmail.com).

Objective: Little information is available about surgical outcomes in patients with multivalvular endocarditis. The aim of this article is to review the 21-year experience with surgical treatment of patients with multivalvular endocarditis at our institution and, in particular, to determine the incidence, pathologic status, diagnosis, surgical strategies, and outcomes of patients with this disease.

Methods: From January 1986 to December 2006, a total of 48 patients (40 men, 8 women), with a mean age of 42 ± 12 years, underwent surgery for multivalvular endocarditis. Endocarditis was active in 32 patients and healed in 16. Preoperative transthoracic echocardiographic evaluation was performed in all 48 patients with addition of transesophageal echocardiography in 22 (45.8%). Intraoperative findings showed that the endocarditis involved mostly the mitral and aortic valves (40/48 patients). Triple or quadruple valve involvement was found in 1 and 2 patients, respectively. Preoperative, perioperative, and postoperative data were retrospectively analyzed and risk factors for early and late survival were determined.

Results: In only 24 (50.0%) patients was multivalvular endocarditis diagnosed by preoperative transthoracic echocardiography; 17 (77.3%) patients had multivalvular endocarditis confirmed by preoperative transesophageal echocardiography. The 30-day hospital mortality was 12.5% (n = 6). Preoperative renal failure, New York Heart Association class IV, and emergency surgery were identified as independent risk factors for hospital mortality. Overall long-term survival was 74% ± 6% at 5 years and 62% ± 3% at 10 years. Multivariate analysis revealed that renal failure and recurrent endocarditis were associated with increased late mortality. Ten-year freedom from recurrent endocarditis was 74% ± 5% and 10-year freedom from reoperation was 73% ± 6%.

Conclusions: In our institution, multivalvular endocarditis was diagnosed by transthoracic echocardiography in only half of the patients. Intraoperative transesophageal echocardiography provided a more effective means to identify this disease. Radical resection of all infected tissues for patients with multivalvular endocarditis and additional intraoperative interventions, depending on the intraoperative pathologic condition, produced satisfactory in-hospital and long-term results, similar to those in patients with a single infected heart valve.

Abbreviations and Acronyms CHD = congenital heart disease; CI = confidence interval; MVE = multivalvular endocarditis; NVE = native valve endocarditis; OR = odds ratio; TEE = transesophageal echocardiography; TTE = transthoracic echocardiography






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