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The Journal of Thoracic and Cardiovascular Surgery, Vol 71, 64-71, Copyright © 1976 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
JD Hill, JL Ratliff, JC Parrott, M Lamy, RJ Fallat, E Koeniger, EM Yaeger and G Whitmer
Forty-two patients underwent open-lung biopsy during the early phase of
acute respiratory insufficiency. Correlation between the gross appearance
of the lung at operation and the microscopic findings was good. Although
only fair correlation was found between lung and tracheal cultures, the
findings of two positive cultures in the lung only was of utmost
importance. Biopsying multiple areas from the same operation showed
identical pathology in 86 per cent of cases. The mortality rate of
open-lung biopsy was zero; the morbidity rate was 4 per cent. The over-all
survival rate of acute respiratory insufficiency (ARI) due to trauma was 39
per cent; that of pneumonia, 11 per cent. In 17 (33 percent) patients
specific diagnoses and/or specific therapies were employed as a direct
result of the biopsy or the thoracotomy. The incidence and prognostic
implications of fibrosis and microthromboembolism are presented and
discussed. Open-lung biopsy has been extremely safe and valuable in
characterizing and managing ARI.
ARTICLES
Pulmonary pathology in acute respiratory insufficiency: lung biopsy as a diagnostic tool
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