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The Journal of Thoracic and Cardiovascular Surgery, Vol 75, 877-885, Copyright © 1978 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
DJ Hearse, DA Stewart and MV Braimbridge
The increasing use of coronary infusates for the protection of the human
heart drug ischemic cardiac arrest has placed great emphasis on the need
for a rational and safe formulation of any infusion solution. Using a rat
heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have
found magnesium to be a highly effective component of protective infusates
which can be additive to hypothermia and other protective agents. However,
the concentration of magnesium bears a complex relationship to the degree
of protection, a fact which stresses the need for the establishment of the
correct concentration for optimal protection.
ARTICLES
Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates
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