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The Journal of Thoracic and Cardiovascular Surgery, Vol 77, 109-118, Copyright © 1979 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
A Rendas, S Lennox and L Reid
Aorta-pulmonary shunts were produced in growing pigs, 4 to 12 weeks of age,
by anastomosing the thoracic descending aorta to the pulmonary trunk, and
the animals were followed for periods of 1 to 3 months. Correlation between
the hemodynamic findings and the lung structure, analyzed by quantitative
methods, showed that the young group (operated upon at 4 weeks of age)
developed more severe pulmonary hypertension with increased muscularization
of arteries of all sizes and reduction in the size of those running with
respiratory bronchioli and beyond. Since this response is similar to that
seen in cases of left-to-right shunt associated with congenital heart
defects and pulmonary hypertension early in life, it seems that the present
experiments reproduce the early response of the growing lung to such
hemodynamic disturbance.
ARTICLES
Aorta-pulmonary shunts in growing pigs. Functional and structural assessment of the changes in the pulmonary circulation
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