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The Journal of Thoracic and Cardiovascular Surgery, Vol 78, 217-222, Copyright © 1979 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association


ARTICLES

Iatrogenic myocardial edema with potassium cardioplegia

RP Foglia, DL Steed, DM Follette, E DeLand and GD Buckberg

Postischemic myocardial edema depresses left ventricular function and coronary perfusion. Pharmacologic cardioplegia is being used increasingly to enhance myocardial protection during cardiac operations. In the present study we varied the colloid osmotic and osmotic pressures and the infusion pressures of four cardioplegic solutions to determine their respective roles in producing or preventing myocardial edema in a nonischemic setting. We found that myocardial edema during potassium cardioplegia (1) is independent of infusion pressures, (2) is caused by isosmotic crystalloid solutions, (3) is worsened by hyposmolar crystalloid solutions, (4) is avoided by the addition of colloid, and (5) is avoided if the solution is made hyperosmotic with the addition of mannitol.


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