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The Journal of Thoracic and Cardiovascular Surgery, Vol 78, 217-222, Copyright © 1979 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
RP Foglia, DL Steed, DM Follette, E DeLand and GD Buckberg
Postischemic myocardial edema depresses left ventricular function and
coronary perfusion. Pharmacologic cardioplegia is being used increasingly
to enhance myocardial protection during cardiac operations. In the present
study we varied the colloid osmotic and osmotic pressures and the infusion
pressures of four cardioplegic solutions to determine their respective
roles in producing or preventing myocardial edema in a nonischemic setting.
We found that myocardial edema during potassium cardioplegia (1) is
independent of infusion pressures, (2) is caused by isosmotic crystalloid
solutions, (3) is worsened by hyposmolar crystalloid solutions, (4) is
avoided by the addition of colloid, and (5) is avoided if the solution is
made hyperosmotic with the addition of mannitol.
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Iatrogenic myocardial edema with potassium cardioplegia
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