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The Journal of Thoracic and Cardiovascular Surgery, Vol 79, 738-740, Copyright © 1980 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
P van der Starre, D Sinclair, J Damen and H Brummelhuis
The hypotensive effect of stable plasma protein solution (SPPS) is a
well-known phenomenon, causing serious problems in surgical patients and
patients supported by cardiopulmonary bypass. Kinins are believed to be
responsible. A study was made to prevent this hypotension by adding C1
esterase inhibitor to the SPPS and comparing this with 5% human albumin.
The results shows a significant difference between the effects of SPPS and
SPPS plus C1 esterase inhibitor infusion on bypass. Five percent human
albumin did not cause hypotension. Possible sequelae are discussed.
ARTICLES
Inhibition of the hypotensive effect of plasma protein solutions by C1 esterase inhibitor
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