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The Journal of Thoracic and Cardiovascular Surgery, Vol 79, 738-740, Copyright © 1980 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association


ARTICLES

Inhibition of the hypotensive effect of plasma protein solutions by C1 esterase inhibitor

P van der Starre, D Sinclair, J Damen and H Brummelhuis

The hypotensive effect of stable plasma protein solution (SPPS) is a well-known phenomenon, causing serious problems in surgical patients and patients supported by cardiopulmonary bypass. Kinins are believed to be responsible. A study was made to prevent this hypotension by adding C1 esterase inhibitor to the SPPS and comparing this with 5% human albumin. The results shows a significant difference between the effects of SPPS and SPPS plus C1 esterase inhibitor infusion on bypass. Five percent human albumin did not cause hypotension. Possible sequelae are discussed.


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D. Scott, P.J. Hore, J. Cannata, K. Mason, B. Treagus, and J. Mullaly
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[Abstract] [PDF]


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C. Dellora, P. Minola, and F. Parodi
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[Abstract] [PDF]




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