HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thomson, R. Articles by Towers, M. Search for Related Content PubMed PubMed Citation Articles by Thomson, R. Articles by Towers, M.

The Journal of Thoracic and Cardiovascular Surgery, Vol 79, 896-903, Copyright © 1980 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

The use of "fresh" unstented homograft valves for replacement of the aortic valve. Analysis of 8 years' experience

R Thomson, M Yacoub, M Ahmed, W Somerville and M Towers

Between August, 1969 and May 1978, 679 patients underwent homograft replacement of the aortic valve. Isolated elective valve replacement was performed in 411 patients. Thirty-four patients had total aortic root replacement with reimplantation of the coronary arteries. There were 16 early deaths (3.9%) and 43 late deaths (10.5%) during a follow- up between 3 and 102 months (mean 47 months). Actuarial analysis showed 87% survival at 5 years and 81% at 8 years. Valve failure occurred in 24 patients (5.9%) owing to prolapse of one cusp in eight patients (2.0%), infective endocarditis in seven patients (1.7%), and degeneration of the valve in nine patients (2.2%). Degenerative valve failure was encountered after the fourth year with an incidence of 4.8% of patients at risk and occurred only in grafts from donors over the age of 65 years. Diastolic murmurs were present in 28% of patients followed beyond 1 month and increased very slightly with time. Systemic embolism was not recorded in any patient despite the fact that anticoagulants were not used. The clinical results were judged to be good or excellent in 89% of patients. It is concluded that homograft replacement of the aortic valve gives satisfactory results with a low incidence of late valve failure.

This article has been cited by other articles:

				G. Perri, A. Polito, C. Esposito, S. B. Albanese, P. Francalanci, G. Pongiglione, and A. Carotti Early and late failure of tissue-engineered pulmonary valve conduits used for right ventricular outflow tract reconstruction in patients with congenital heart disease Eur J Cardiothorac Surg, January 4, 2012; (2012) ezr221v1. [Abstract] [Full Text] [PDF]

				P. Stelzer Stentless Aortic Valve Replacement: Porcine and Pericardial Card. Surg. Adult, January 1, 2008; 3(2008): 915 - 934. [Full Text]

				O. Lund, V. Chandrasekaran, R. Grocott-Mason, H. Elwidaa, R. Mazhar, A. Khaghani, A. Mitchell, C. Ilsley, and M. H. Yacoub PRIMARY AORTIC VALVE REPLACEMENT WITH ALLOGRAFTS OVER TWENTY-FIVE YEARS: VALVE-RELATED AND PROCEDURE-RELATED DETERMINANTS OF OUTCOME J. Thorac. Cardiovasc. Surg., January 1, 1999; 117(1): 77 - 91. [Abstract] [Full Text] [PDF]

				M. Albertucci, K. Wong, M. Petrou, A. Mitchell, J. Somerville, S. Theodoropoulos, and M. Yacoub The use of unstented homograft valves for aortic valve reoperationsReview of a twenty-three-year experience J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 152 - 161. [Abstract] [Full Text]

				P. W. Domkowski, R. H. Messier, D. G. Crescenzo, H. S. Aly, A. S. Abd-Elfattah, S. L. Hilbert, R. B. Wallace, and R. A. Hopkins Preimplantation alteration of adenine nucleotides in cryopreserved heart valves Ann. Thorac. Surg., February 1, 1993; 55(2): 413 - 419. [Abstract] [PDF]

				E. L. Jones Freehand homograft aortic valve replacement--the learning curve: A technical analysis of the first 31 patients Ann. Thorac. Surg., July 1, 1989; 48(1): 26 - 32. [Abstract] [PDF]

				S. H. RAHIMTOOLA The Need for Cardiac Catheterization and Angiography in Valvular Heart Disease is NotDisproven Ann Intern Med, September 1, 1982; 97(3): 433 - 439. [Abstract] [PDF]