HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bethencourt, D. M. Articles by Laks, H. Search for Related Content PubMed PubMed Citation Articles by Bethencourt, D. M. Articles by Laks, H.

The Journal of Thoracic and Cardiovascular Surgery, Vol 81, 440-449, Copyright © 1981 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Importance of edema and compliance changes during 24 hours of preservation of the dog heart

DM Bethencourt and H Laks

The development of myocardial edema and the changes in compliance during long-term preservation and reperfusion of 10 dog hearts were studied. Krebs solution, modified by the addition of potassium chloride (20 mEq/L), was used for 24 hours of low-pressure perfusion (15 mm Hg), at 4 degrees C. The hearts then were reperfused with the use of a support dog. Gravimetric heart water of myocardial biopsy tissue increased from control values of 78.0 +/- 0.8 to 82.8 +/- 0.6 ml/100 gm at 1 hour (p less than 0.01) and to 84.2 +/- 0.3 ml/100 gm after 24 hours of preservation (p less than 0.05 compared to 1 hour). After reperfusion, heart water decreased to 82.8 +/- 0.3 ml/100 gm (p less than 0.05). Passive compliance during preservation, obtained using an inflatable intraventricular balloon, decreased from 1.49 +/- 0.03 ml/mm Hg at 1 hour to 0.65 +/- 0.14 ml/mm Hg at 24 hours (p less than 0.05). High-energy phosphate levels were unchanged at 1 and 24 hours of preservation. Light and electron microscopy at 24 hours of preservation showed marked pericapillary edema and excellent preservation of intracellular structures. During reperfusion, ventricular function curves and dp/dt (2,841 +/- 581 mm Hg/sec) were comparable to previously reported control values. Passive compliance at 24 hours correlated with the diastolic compliance during reperfusion (p less than 0.01). The change in passive compliance during preservation also correlated with the change in coronary vascular resistance, a previously reported index of myocardial viability (p less than 0.05). This study has shown that the change in passive compliance of the heart during perfusion correlates with the adequacy of myocardial preservation and provides an additional index of preserved heart viability.

This article has been cited by other articles:

				T. P. Fitton, C. J. Barreiro, P. N. Bonde, C. Wei, F. Gage, R. Rodriguez, and J. V. Conte Attenuation of DNA Damage in Canine Hearts Preserved by Continuous Hypothermic Perfusion Ann. Thorac. Surg., November 1, 2005; 80(5): 1812 - 1820. [Abstract] [Full Text] [PDF]

				D. G. Rabkin, S. E. Cabreriza, J. C. LaCorte, A. D. Weinberg, L. Coku, R. Walsh, R. Mosca, and H. M. Spotnitz Sodium-hydrogen exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1499 - 1509. [Abstract] [Full Text] [PDF]

				Y.-I. L. Kim, P. Herijgers, S. K. Laycock, A. Van Lommel, E. Verbeken, and W. J. Flameng Na+/H+ exchange inhibition improves long-term myocardial preservation Ann. Thorac. Surg., August 1, 1998; 66(2): 436 - 442. [Abstract] [Full Text] [PDF]

				D. K. Nickless, M. Rabinov, S. M. Richards, R. A.J. Conyers, and F. L. Rosenfeldt Continuous Perfusion Improves Preservation of Donor Rat Hearts: Importance of the Implantation Phase Ann. Thorac. Surg., May 1, 1998; 65(5): 1265 - 1272. [Abstract] [Full Text] [PDF]

				M. Tonz, O. N. Krogmann, O. M. Hess, B. Leskosek, T. Mihaljevic, L. K. von Segesser, and M. I. Turina Effect of Intermittent Warm Blood Cardioplegia on Functional Recovery After Prolonged Cardiac Arrest Ann. Thorac. Surg., October 1, 1996; 62(4): 1146 - 1151. [Abstract] [Full Text]

				R. Ferrera, R. Forrat, P. Marcsek, M. de Lorgeril, and G. Dureau Importance of Initial Coronary Artery Flow After Heart Procurement to Assess Heart Viability Before Transplantation Circulation, January 15, 1995; 91(2): 257 - 261. [Abstract] [Full Text]

				J. Chalmers and T. Graham Review article : Mechanical ventricular support in the management of postcardiotomy cardiogenic shock Perfusion, October 1, 1989; 4(4): 243 - 253. [Abstract] [PDF]

				M. Szycher, W. Clay, D. Gernes, and C. Sherman Thermedics' Approach to Ventricular Support Systems J Biomater Appl, January 1, 1986; 1(1): 39 - 105. [Abstract] [PDF]