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The Journal of Thoracic and Cardiovascular Surgery, Vol 81, 485-492, Copyright © 1981 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Four-year follow-up on the Albany experience with intrapleural BCG in lung cancer

MF McKneally, C Maver, L Lininger, HW Kausel, JB McIlduff, TM Older, ED Foster and RD Alley

One hundred sixty-nine patients were entered into randomized controlled studies of intrapleural bacille Calmette Guerin (BCG) immunotherapy after surgical resection of lung cancer. Long-term follow-up of our initial series of BCG-treated patients with Stage I disease continues to indicate that this treatment was superior to that given to control patients. The recurrence rate in the control population was high, 62% at 3 years. The recurrence rate was 33% at 3 years in the BCG-treated group. A negative preoperative tuberculin test and squamous cell histologic type were favorable prognostic factors for BCG-treated patients. The survival of patients with more advanced disease was not improved by BCG immunotherapy.




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Copyright © 1981 by The American Association for Thoracic Surgery.